Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

The Polycomb group (PcG) of proteins defines a subset of factors that physically associate
and function to maintain the positional identity of cells from the embryo to adult stages. PcG …

Summary Enhancer of Zeste 2 (EZH2) is the enzymatic subunit of Polycomb Repressive
Complex 2 (PRC2), which catalyzes histone H3 lysine 27 trimethylation (H3K27me3) at …

Stem cells undergo a shift in metabolic substrate utilization during specification and/or
differentiation, a process that has been termed metabolic reprogramming. Here, we report …

Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

Transcription factors and DNA regulatory binding motifs are fundamental components of the
gene regulatory network. Here, by using genome-wide binding profiling, we show extensive …

Abstract Polycomb repressive complex 2 (PRC2) is a histone methyltransferase required for
epigenetic silencing during development and cancer. Long noncoding RNAs (lncRNAs) …

Naturally occurring variations of Polycomb repressive complex 1 (PRC1) comprise a core
assembly of Polycomb group proteins and additional factors that include, surprisingly …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

Recent studies point to a pivotal role of Polycomb repressive complex 2 (PRC2) in stem cell
function and cancer. Loss-of-function approaches targeting individual PRC2 subunits have …