Neuronal wiring diagram of an adult brain

S Dorkenwald, A Matsliah, AR Sterling, P Schlegel… - Nature, 2024 - nature.com
Connections between neurons can be mapped by acquiring and analysing electron
microscopic brain images. In recent years, this approach has been applied to chunks of …

Multisensory learning binds neurons into a cross-modal memory engram

Z Okray, PF Jacob, C Stern, K Desmond, N Otto… - Nature, 2023 - nature.com
Associating multiple sensory cues with objects and experience is a fundamental brain
process that improves object recognition and memory performance. However, neural …

[HTML][HTML] Network statistics of the whole-brain connectome of Drosophila

A Lin, R Yang, S Dorkenwald, A Matsliah, AR Sterling… - Nature, 2024 - nature.com
Brains comprise complex networks of neurons and connections, similar to the nodes and
edges of artificial networks. Network analysis applied to the wiring diagrams of brains can …

Octopamine in the mushroom body circuitry for learning and memory

M Selcho - Learning & Memory, 2024 - learnmem.cshlp.org
Octopamine, the functional analog of noradrenaline, modulates many different behaviors
and physiological processes in invertebrates. In the central nervous system, a few …

Sensory encoding and memory in the mushroom body: signals, noise, and variability

M Parnas, JE Manoim, AC Lin - Learning & Memory, 2024 - learnmem.cshlp.org
To survive in changing environments, animals need to learn to associate specific sensory
stimuli with positive or negative valence. How do they form stimulus-specific memories to …

[HTML][HTML] Driver lines for studying associative learning in Drosophila

Y Shuai, M Sammons, G Sterne, K Hibbard, H Yang… - eLife, 2024 - elifesciences.org
The mushroom body (MB) is the center for associative learning in insects. In Drosophila,
intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the …

Lateral axonal modulation is required for stimulus-specific olfactory conditioning in Drosophila

JE Manoim, AM Davidson, S Weiss, T Hige, M Parnas - Current Biology, 2022 - cell.com
Effective and stimulus-specific learning is essential for animals' survival. Two major
mechanisms are known to aid stimulus specificity of associative learning. One is accurate …

[HTML][HTML] Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning

J Zeng, X Li, R Zhang, M Lv, Y Wang, K Tan, X Xia… - Neuron, 2023 - cell.com
The coincidence between conditioned stimulus (CS) and unconditioned stimulus (US) is
essential for associative learning; however, the mechanism regulating the duration of this …

[HTML][HTML] Structured sampling of olfactory input by the fly mushroom body

Z Zheng, F Li, C Fisher, IJ Ali, N Sharifi, S Calle-Schuler… - Current Biology, 2022 - cell.com
Associative memory formation and recall in the fruit fly Drosophila melanogaster is
subserved by the mushroom body (MB). Upon arrival in the MB, sensory information …

Response competition between neurons and antineurons in the mushroom body

E Vrontou, LN Groschner, S Szydlowski, R Brain… - Current Biology, 2021 - cell.com
The mushroom bodies of Drosophila contain circuitry compatible with race models of
perceptual choice. When flies discriminate odor intensity differences, opponent pools of αβ …