Emerging concepts in pseudoenzyme classification, evolution, and signaling
The 21st century is witnessing an explosive surge in our understanding of pseudoenzyme-
driven regulatory mechanisms in biology. Pseudoenzymes are proteins that have sequence …
driven regulatory mechanisms in biology. Pseudoenzymes are proteins that have sequence …
The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases
AV Jacobsen, JM Murphy - Biochemical Society Transactions, 2017 - portlandpress.com
Over the past decade, our understanding of the mechanisms by which pseudokinases,
which comprise∼ 10% of the human and mouse kinomes, mediate signal transduction has …
which comprise∼ 10% of the human and mouse kinomes, mediate signal transduction has …
AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network
A Abu-Thuraia, MA Goyette, J Boulais… - Nature …, 2020 - nature.com
Aberrant expression of receptor tyrosine kinase AXL is linked to metastasis. AXL can be
activated by its ligand GAS6 or by other kinases, but the signaling pathways conferring its …
activated by its ligand GAS6 or by other kinases, but the signaling pathways conferring its …
Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling
PEAK pseudokinases regulate cell migration, invasion and proliferation by recruiting key
signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their …
signaling proteins to the cytoskeleton. Despite lacking catalytic activity, alteration in their …
The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization
The pseudokinase group encompasses some 10% of protein kinases, but pseudokinases
diverge from canonical kinases in key motifs. The two members of the small new kinase …
diverge from canonical kinases in key motifs. The two members of the small new kinase …
Structure of SgK223 pseudokinase reveals novel mechanisms of homotypic and heterotypic association
The mammalian pseudokinase SgK223, and its structurally related homologue SgK269, are
oncogenic scaffolds that nucleate the assembly of specific signalling complexes and …
oncogenic scaffolds that nucleate the assembly of specific signalling complexes and …
Dimerization of the Pragmin pseudo-kinase regulates protein tyrosine phosphorylation
C Lecointre, V Simon, C Kerneur, F Allemand… - Structure, 2018 - cell.com
The pseudo-kinase and signaling protein Pragmin has been linked to cancer by regulating
protein tyrosine phosphorylation via unknown mechanisms. Here we present the crystal …
protein tyrosine phosphorylation via unknown mechanisms. Here we present the crystal …
The PEAK family of pseudokinases, their role in cell signalling and cancer
The study of pseudokinases has uncovered that catalysis‐independent functions play a
critical role in cell signalling regulation. However, how pseudokinases dynamically …
critical role in cell signalling regulation. However, how pseudokinases dynamically …
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
EphB6 and EphA10 are two poorly characterised pseudokinase members of the Eph
receptor family, which collectively serves as mediators of contact-dependent cell–cell …
receptor family, which collectively serves as mediators of contact-dependent cell–cell …
Characterization of the Src-regulated kinome identifies SGK1 as a key mediator of Src-induced transformation
Despite significant progress, our understanding of how specific oncogenes transform cells is
still limited and likely underestimates the complexity of downstream signalling events. To …
still limited and likely underestimates the complexity of downstream signalling events. To …