The adult mammalian heart contains abundant interstitial and perivascular fibroblasts that
expand following injury and play a reparative role but also contribute to maladaptive fibrotic …

Collagen provides mechanical and biological support for virtually all human tissues in the
extracellular matrix (ECM). Its defining molecular structure, the triple-helix, could be …

Repair of the infarcted heart requires TGF-β/Smad3 signaling in cardiac myofibroblasts.
However, TGF-β–driven myofibroblast activation needs to be tightly regulated in order to …

The heart contains a population of resident macrophages that markedly expands following
injury through recruitment of monocytes and through proliferation of macrophages. In …

BACKGROUND: Pericytes have been implicated in tissue repair, remodeling, and fibrosis.
Although the mammalian heart contains abundant pericytes, their fate and involvement in …

Reliable tools for macrophage identification in mouse tissues are critical for studies
investigating inflammatory and reparative responses. Transgenic reporter mice and anti …

Macrophages sense changes in the extracellular matrix environment through the integrins
and play a central role in regulation of the reparative response after myocardial infarction …

Background Although miR-125b plays a crucial role in many human cancers. However, its
function in heart failure (HF) remains unclear. Our study aimed to investigate its involvement …

Recent studies have identified FoxL1+-telocytes (TC FoxL1+) as key players in gut epithelial-
mesenchymal interactions which can determine the colonic microenvironment. Bone …

Cis-peptide bonds are rare in proteins, and building blocks less favorable to the trans-
conformer have been considered destabilizing. Although proline tolerates the cis-conformer …