Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Permeability transition (PT) is an increase in mitochondrial inner membrane permeability
that can lead to a disruption of mitochondrial function and cell death. PT is responsible for …

Cyclophilin D (CyPD) is an important mitochondrial chaperone protein whose mechanism of
action remains a mystery. It is well known for regulating mitochondrial function and coupling …

Tau is an essential protein that physiologically promotes the assembly and stabilization of
microtubules, and participates in neuronal development, axonal transport, and neuronal …

The execution of proper Ca 2+ signaling requires close apposition between the
endoplasmic reticulum (ER) and mitochondria. Hence, Ca 2+ released from the ER is “quasi …

Mitochondria is not only a dynamic organelle that produces ATP, but is also an important
contributor to cell functions in both development and cell death processes. These …

Over the past 30 years the mitochondrial permeability transition–the permeabilization of the
inner mitochondrial membrane due to the opening of a wide pore–has progressed from …

Introduction Sepsis-induced myocardial dysfunction (SIMD) is a condition manifested by an
intrinsic myocardial systolic and diastolic dysfunction during sepsis, which is associated with …

Mitochondrial permeability transition pore (mPTP) opening allows free movement of ions
and small molecules leading to mitochondrial membrane depolarization and ATP depletion …