Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

The blood-brain barrier: Physiology and strategies for drug delivery

R Pandit, L Chen, J Götz - Advanced drug delivery reviews, 2020 - Elsevier
The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

Transcranial focused ultrasound (tFUS) and transcranial unfocused ultrasound (tUS) neuromodulation: from theoretical principles to stimulation practices

L Di Biase, E Falato, V Di Lazzaro - Frontiers in neurology, 2019 - frontiersin.org
Transcranial focused ultrasound is an emerging technique for non-invasive
neurostimulation. Compared to magnetic or electric non-invasive brain stimulation, this …

High-intensity focused ultrasound: past, present, and future in neurosurgery

SA Quadri, M Waqas, I Khan, MA Khan, SS Suriya… - Neurosurgical …, 2018 - thejns.org
Since Lynn and colleagues first described the use of focused ultrasound (FUS) waves for
intracranial ablation in 1942, many strides have been made toward the treatment of several …

Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results …

B Davidson, C Hamani, JS Rabin, M Goubran… - Molecular …, 2020 - nature.com
Obsessive compulsive disorder (OCD) and major depressive disorder (MDD) are common,
often refractory, neuropsychiatric conditions for which new treatment approaches are …

Ablative brain surgery: an overview

A Franzini, S Moosa, D Servello, I Small… - International Journal …, 2019 - Taylor & Francis
Background: Ablative therapies have been used for the treatment of neurological disorders
for many years. They have been used both for creating therapeutic lesions within …

Transcranial ultrasound innovations ready for broad clinical application

R Beisteiner, AM Lozano - Advanced Science, 2020 - Wiley Online Library
Brain diseases are one of the most important problems in our rapidly ageing society.
Currently, there are not many effective medications and surgical options are limited due to …

Focused ultrasound in neuroscience. State of the art and future perspectives

GR Giammalva, C Gagliardo, S Marrone, F Paolini… - Brain sciences, 2021 - mdpi.com
Transcranial MR-guided Focused ultrasound (tcMRgFUS) is a surgical procedure that
adopts focused ultrasounds beam towards a specific therapeutic target through the intact …

Echo‐focusing in transcranial focused ultrasound thalamotomy for essential tremor: a feasibility study

RM Jones, Y Huang, Y Meng, N Scantlebury… - Movement …, 2020 - Wiley Online Library
Background Transcranial magnetic resonance–guided focused ultrasound (TcMRgFUS)
systems currently employ computed tomography (CT)–based aberration corrections, which …

Update in the clinical application of focused ultrasound

E Natera-Villalba, M Matarazzo… - Current Opinion in …, 2022 - journals.lww.com
Update in the clinical application of focused ultrasound : Current Opinion in Neurology Update in
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