Microsatellite repeat DNA is best known for its length mutability, which is implicated in
several neurological diseases and cancers, and often exploited as a genetic marker. Less …

The most stable structure of DNA is the canonical right-handed double helix termed B DNA.
However, certain environments and sequence motifs favor alternative conformations, termed …

Tandem repeats are genomic elements that are prone to changes in repeat number and are
thus often polymorphic. These sequences are found at a high density at the start of human …

Short tandem repeat (STR) mutations may comprise more than half of the mutations in
eukaryotic coding DNA, yet STR variation is rarely examined as a contributor to complex …

Abstract PRKACB (Protein Kinase CAMP-Activated Catalytic Subunit Beta) is predominantly
expressed in the brain, and regulation of this gene links to neuroprotective effects against …

Adaptive evolution may be linked with the genomic distribution and function of short tandem
repeats (STRs). Proximity of the core promoter STRs to the+ 1 transcription start site (TSS) …

Kinship plays a fundamental role in the evolution of social systems and is considered a key
driver of group living. To understand the role of kinship in the formation and maintenance of …

Alteration in gene expression levels underlies many of the phenotypic differences across
species. Because of their highly mutable nature, proximity to the+ 1 transcription start site …

Abstract Background Tandem repeats (TRs) are unstable regions commonly found within
genomes that have consequences for evolution and disease. In humans, polymorphic TRs …

The protein kinase C alpha (PRKCA) gene, encoding a Th17-cell-selective kinase, was
repeatedly associated with multiple sclerosis (MS), but the underlying pathogenic …