PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer
H Deng, Y Chen, P Li, Q Hang, P Zhang… - Cancer Pathogenesis …, 2023 - mednexus.org
Small cell lung cancer (SCLC) is a highly aggressive tumor type for which limited therapeutic
progress has been made. Platinum-based chemotherapy with or without thoracic …
progress has been made. Platinum-based chemotherapy with or without thoracic …
PI3K/mTOR inhibitors promote G6PD autophagic degradation and exacerbate oxidative stress damage to radiosensitize small cell lung cancer
H Deng, Y Chen, L Wang, Y Zhang, Q Hang, P Li… - Cell Death & …, 2023 - nature.com
Our previous study revealed that PI3K/AKT/mTOR signaling was associated with SCLC
radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells …
radioresistance. SBC2 cells were used as primary radioresistance models, while H446 cells …
[HTML][HTML] Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication
SARS-CoV-2 infections are rapidly spreading around the globe. The rapid development of
therapies is of major importance. However, our lack of understanding of the molecular …
therapies is of major importance. However, our lack of understanding of the molecular …
MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors
B Yang, X Li, Y Fu, E Guo, Y Ye, F Li, S Liu, R Xiao… - Cancer research, 2021 - AACR
Mutant KRAS tumors are associated with poor outcomes, at least in part, due to decreased
therapeutic sensitivity. Here, we show that KRAS mutations are associated with resistance to …
therapeutic sensitivity. Here, we show that KRAS mutations are associated with resistance to …
Design, synthesis, and biological evaluation of MEK PROTACs
S Vollmer, D Cunoosamy, H Lv, H Feng… - Journal of Medicinal …, 2019 - ACS Publications
PROteolysis TArgeting Chimeras (PROTACs) targeting the degradation of MEK have been
designed based on allosteric MEK inhibitors. Inhibition of the phosphorylation of ERK1/2 …
designed based on allosteric MEK inhibitors. Inhibition of the phosphorylation of ERK1/2 …
[HTML][HTML] Interleukin-22 inhibits respiratory syncytial virus production by blocking virus-mediated subversion of cellular autophagy
Respiratory syncytial virus (RSV) infection can cause severe bronchiolitis in infants requiring
hospitalization, whereas the elderly and immunocompromised are prone to RSV-induced …
hospitalization, whereas the elderly and immunocompromised are prone to RSV-induced …
EPAC regulates melanoma growth by stimulating mTORC1 signaling and loss of EPAC signaling dependence correlates with melanoma progression
A Krishnan, AI Bhasker, MK Singh, CI Rodriguez… - Molecular Cancer …, 2022 - AACR
Exchange proteins directly activated by cAMP (EPAC) belong to a family of RAP guanine
nucleotide exchange factors (RAPGEF). EPAC1/2 (RAPGEF3/4) activates RAP1 and the …
nucleotide exchange factors (RAPGEF). EPAC1/2 (RAPGEF3/4) activates RAP1 and the …
Fragment-based discovery of novel allosteric MEK1 binders
P Di Fruscia, F Edfeldt, I Shamovsky… - ACS Medicinal …, 2021 - ACS Publications
The MEK1 kinase plays a critical role in key cellular processes, and as such, its dysfunction
is strongly linked to several human diseases, particularly cancer. MEK1 has consequently …
is strongly linked to several human diseases, particularly cancer. MEK1 has consequently …
Dual role for a MEK inhibitor as a modulator of inflammation and host defense mechanisms with potential therapeutic application in COPD
Background Unlike p38 mitogen-activated protein Kinases (MAPK) that has been
extensively studied in the context of lung-associated pathologies in COPD, the role of the …
extensively studied in the context of lung-associated pathologies in COPD, the role of the …
MEK/ERK MAP kinase limits poly I: C‐induced antiviral gene expression in RAW264. 7 macrophages by reducing interferon‐beta expression
SM Freed, DS Baldi, JA Snow, SR Athen… - FEBS …, 2021 - Wiley Online Library
Toll‐like receptor 3 (TLR3) recognizes viral double‐stranded RNA (or the synthetic dsRNA
analog poly I: C) and induces a signal transduction pathway that results in activation of …
analog poly I: C) and induces a signal transduction pathway that results in activation of …