Cellular host factors for SARS-CoV-2 infection

J Baggen, E Vanstreels, S Jansen, D Daelemans - Nature Microbiology, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

Azaindole derivatives as potential kinase inhibitors and their SARs elucidation

G Fang, H Chen, Z Cheng, Z Tang, Y Wan - European Journal of Medicinal …, 2023 - Elsevier
Currently, heterocycles have occupied an important position in the fields of drug design.
Among them, azaindole moiety is regarded as one privileged scaffold to develop therapeutic …

Feasibility and biological rationale of repurposing sunitinib and erlotinib for dengue treatment

SY Pu, F Xiao, S Schor, E Bekerman, F Zanini… - Antiviral research, 2018 - Elsevier
There is an urgent need for strategies to combat dengue virus (DENV) infection; a major
global threat. We reported that the cellular kinases AAK1 and GAK regulate intracellular …

Viral journeys on the intracellular highways

M Robinson, S Schor, R Barouch-Bentov… - Cellular and Molecular …, 2018 - Springer
Viruses are obligate intracellular pathogens that are dependent on cellular machineries for
their replication. Recent technological breakthroughs have facilitated reliable identification …

Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for antiviral strategies

M Karim, S Saul, L Ghita, MK Sahoo, C Ye, N Bhalla… - Antiviral Research, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose serious threats to …

Recent developments in the use of kinase inhibitors for management of viral infections

R Raghuvanshi, SB Bharate - Journal of medicinal chemistry, 2021 - ACS Publications
Kinases are a group of therapeutic targets involved in the progression of numerous
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …

Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity

S Verdonck, SY Pu, FJ Sorrell, JM Elkins… - Journal of medicinal …, 2019 - ACS Publications
There are currently no approved drugs for the treatment of emerging viral infections, such as
dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine–threonine …

MARCH8 ubiquitinates the hepatitis C virus nonstructural 2 protein and mediates viral envelopment

S Kumar, R Barouch-Bentov, F Xiao, S Schor, S Pu… - Cell reports, 2019 - cell.com
The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly
and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination …

A plant RNA virus hijacks endocytic proteins to establish its infection in plants

G Wu, X Cui, Z Dai, R He, Y Li, K Yu… - The Plant …, 2020 - Wiley Online Library
Endocytosis and endosomal trafficking play essential roles in diverse biological processes
including responses to pathogen attack. It is well established that animal viruses enter host …

[HTML][HTML] Cellular factors involved in the hepatitis C virus life cycle

HC Li, CH Yang, SY Lo - World Journal of Gastroenterology, 2021 - ncbi.nlm.nih.gov
The hepatitis C virus (HCV), an obligatory intracellular pathogen, highly depends on its host
cells to propagate successfully. The HCV life cycle can be simply divided into several stages …