Recent research has brought about a clear understanding that successful fracture healing is
based on carefully coordinated cross-talk between inflammatory and bone forming cells. In …

The term osteoimmunology was coined many years ago to describe the research field that
deals with the cross-regulation between bone cells and the immune system. As a matter of …

Purpose The aim of this study was to analyze systematically the influence of the relative
centrifugation force (RCF) on leukocytes, platelets and growth factor release within fluid …

Macrophage has been gradually recognized as a central regulator in tissue regeneration,
and the study of how macrophage mediates biomaterials-induced bone regeneration …

The regulatory role of the immune system in maintaining bone homeostasis and restoring its
functionality, when disturbed due to trauma or injury, has become evident in recent years …

Since the reconstruction of large bone defects remains a challenge, knowledge about the
biology of bone healing is desirable to develop novel strategies for improving the treatment …

The use of endosseous implanted materials is often limited by undesirable effects that may
be due to macrophage-related inflammation. The purpose of this study was to fabricate a …

Human mesenchymal stem cell (hMSC)-derived exosomes have shown regenerative
effects, but their role in osteogenesis and the underlying mechanism are yet to be …

The working hypothesis of guided bone regeneration (GBR) is that the membrane physically
excludes non-osteogenic tissues from interfering with bone healing. However, the …

Extracellular vesicles (EVs), which include exosomes and ectosomes/microvesicles, have
emerged as important intercellular regulators. EVs can interact with surface receptors of …