Regulatory activities of transposable elements: from conflicts to benefits

EB Chuong, NC Elde, C Feschotte - Nature Reviews Genetics, 2017 - nature.com
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …

Transposable elements in human genetic disease

LM Payer, KH Burns - Nature Reviews Genetics, 2019 - nature.com
Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …

Roles for retrotransposon insertions in human disease

DC Hancks, HH Kazazian - Mobile DNA, 2016 - Springer
Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …

Transposable elements as essential elements in the control of gene expression

A Gebrie - Mobile DNA, 2023 - Springer
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …

MicroRNAs and cancer: Key paradigms in molecular therapy

W Tan, B Liu, S Qu, G Liang, W Luo… - Oncology …, 2018 - spandidos-publications.com
MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that performs an
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …

The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs

R Johnson, R Guigó - Rna, 2014 - rnajournal.cshlp.org
Our genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which
are likely to have genetic regulatory functions. It has been proposed that lncRNA are …

The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming

J Durruthy-Durruthy, V Sebastiano, M Wossidlo… - Nature …, 2016 - nature.com
Long intergenic noncoding RNAs (lincRNAs) are derived from thousands of loci in
mammalian genomes and are frequently enriched in transposable elements (TEs). Although …

Development of microRNAs as potential therapeutics against cancer

N Abd-Aziz, NI Kamaruzman, CL Poh - Journal of oncology, 2020 - Wiley Online Library
MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional
level in the cellular regulation process. miRNA expression exerts vital effects on cell growth …

ALUternative regulation for gene expression

LL Chen, L Yang - Trends in cell biology, 2017 - cell.com
Alu elements belong to the primate-specific SINE family of retrotransposons and constitute
almost 11% of the human genome. Alus are transcribed by RNA polymerase (Pol) III and are …

Role of transposable elements in gene regulation in the human genome

A Ali, K Han, P Liang - Life, 2021 - mdpi.com
Transposable elements (TEs), also known as mobile elements (MEs), are interspersed
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …