Regulatory activities of transposable elements: from conflicts to benefits
Transposable elements (TEs) are a prolific source of tightly regulated, biochemically active
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
non-coding elements, such as transcription factor-binding sites and non-coding RNAs. Many …
Transposable elements in human genetic disease
LM Payer, KH Burns - Nature Reviews Genetics, 2019 - nature.com
Transposable elements are abundant in the human genome, and great strides have been
made in pinpointing variations in these repetitive sequences using whole-genome …
made in pinpointing variations in these repetitive sequences using whole-genome …
Roles for retrotransposon insertions in human disease
DC Hancks, HH Kazazian - Mobile DNA, 2016 - Springer
Over evolutionary time, the dynamic nature of a genome is driven, in part, by the activity of
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
transposable elements (TE) such as retrotransposons. On a shorter time scale it has been …
Transposable elements as essential elements in the control of gene expression
A Gebrie - Mobile DNA, 2023 - Springer
Interspersed repetitions called transposable elements (TEs), commonly referred to as mobile
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …
elements, make up a significant portion of the genomes of higher animals. TEs contribute in …
MicroRNAs and cancer: Key paradigms in molecular therapy
W Tan, B Liu, S Qu, G Liang, W Luo… - Oncology …, 2018 - spandidos-publications.com
MicroRNAs (miRNAs) are a type of small non-coding RNA molecule that performs an
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …
important role in post‑transcriptional gene regulation. Since miRNAs were first identified in …
The RIDL hypothesis: transposable elements as functional domains of long noncoding RNAs
Our genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which
are likely to have genetic regulatory functions. It has been proposed that lncRNA are …
are likely to have genetic regulatory functions. It has been proposed that lncRNA are …
The primate-specific noncoding RNA HPAT5 regulates pluripotency during human preimplantation development and nuclear reprogramming
J Durruthy-Durruthy, V Sebastiano, M Wossidlo… - Nature …, 2016 - nature.com
Long intergenic noncoding RNAs (lincRNAs) are derived from thousands of loci in
mammalian genomes and are frequently enriched in transposable elements (TEs). Although …
mammalian genomes and are frequently enriched in transposable elements (TEs). Although …
Development of microRNAs as potential therapeutics against cancer
N Abd-Aziz, NI Kamaruzman, CL Poh - Journal of oncology, 2020 - Wiley Online Library
MicroRNAs (miRNAs) are small noncoding RNAs that function at the posttranscriptional
level in the cellular regulation process. miRNA expression exerts vital effects on cell growth …
level in the cellular regulation process. miRNA expression exerts vital effects on cell growth …
ALUternative regulation for gene expression
Alu elements belong to the primate-specific SINE family of retrotransposons and constitute
almost 11% of the human genome. Alus are transcribed by RNA polymerase (Pol) III and are …
almost 11% of the human genome. Alus are transcribed by RNA polymerase (Pol) III and are …
Role of transposable elements in gene regulation in the human genome
Transposable elements (TEs), also known as mobile elements (MEs), are interspersed
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …
repeats that constitute a major fraction of the genomes of higher organisms. As one of their …