Tumor microenvironment as a therapeutic target in cancer
Y Xiao, D Yu - Pharmacology & therapeutics, 2021 - Elsevier
Tumor microenvironment denotes the non-cancerous cells and components presented in
the tumor, including molecules produced and released by them. The constant interactions …
the tumor, including molecules produced and released by them. The constant interactions …
Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy
MT Masucci, M Minopoli, MV Carriero - Frontiers in oncology, 2019 - frontiersin.org
Tumor Associated Neutrophils (TANs) are engaged into the tumor microenvironment by
cytokines and chemokines, can be distinguished according to their activation and cytokine …
cytokines and chemokines, can be distinguished according to their activation and cytokine …
Exploiting innate immunity for cancer immunotherapy
M Yi, T Li, M Niu, Q Mei, B Zhao, Q Chu, Z Dai, K Wu - Molecular cancer, 2023 - Springer
Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …
However, most of these immunomodulatory strategies focus on harnessing adaptive …
The immune microenvironment in pancreatic cancer
M Huber, CU Brehm, TM Gress, M Buchholz… - International journal of …, 2020 - mdpi.com
The biology of solid tumors is strongly determined by the interactions of cancer cells with
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …
their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal …
Tumor-associated neutrophils in cancer: going pro
The progression of cancer is not only about the tumor cell itself, but also about other
involved players including cancer cell recruited immune cells, their released pro …
involved players including cancer cell recruited immune cells, their released pro …
Contribution to tumor angiogenesis from innate immune cells within the tumor microenvironment: implications for immunotherapy
The critical role of angiogenesis in promoting tumor growth and metastasis is strongly
established. However, tumors show considerable variation in angiogenic characteristics and …
established. However, tumors show considerable variation in angiogenic characteristics and …
[HTML][HTML] Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib
SL Zhou, ZJ Zhou, ZQ Hu, XW Huang, Z Wang… - Gastroenterology, 2016 - Elsevier
Background & Aims Neutrophils can either promote or inhibit tumor progression, depending
on the tumor microenvironment, via release of cytokines. Neither the factors produced by …
on the tumor microenvironment, via release of cytokines. Neither the factors produced by …
The role of tumor-associated neutrophils in colorectal cancer
R Mizuno, K Kawada, Y Itatani, R Ogawa… - International journal of …, 2019 - mdpi.com
Colorectal cancer (CRC) is one of the most common causes of cancer deaths worldwide and
the number of CRC patients is increasing progressively. Despite the improvement of the …
the number of CRC patients is increasing progressively. Despite the improvement of the …
Neutrophils in the tumor microenvironment
DR Powell, A Huttenlocher - Trends in immunology, 2016 - cell.com
Neutrophils are the first responders to sites of acute tissue damage and infection. Recent
studies suggest that in addition to neutrophil apoptosis, resolution of neutrophil inflammation …
studies suggest that in addition to neutrophil apoptosis, resolution of neutrophil inflammation …
Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression
Neutrophils are a vital component of immune protection, yet in cancer they may promote
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …
tumour progression, partly by generating reactive oxygen species (ROS) that disrupts …