Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease–novel insights into cellular communication circuits

M Peiseler, R Schwabe, J Hampe, P Kubes… - Journal of …, 2022 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Hepatic inflammatory responses in liver fibrosis

L Hammerich, F Tacke - Nature Reviews Gastroenterology & …, 2023 - nature.com
Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

MicroRNAs as regulators, biomarkers and therapeutic targets in liver diseases

X Wang, Y He, B Mackowiak, B Gao - Gut, 2021 - gut.bmj.com
MicroRNAs (miRNAs) are small, non-coding RNAs that post-transcriptionally regulate gene
expression by binding to specific mRNA targets and promoting their degradation and/or …

Myeloid‐Cell–Specific IL‐6 Signaling Promotes MicroRNA‐223‐Enriched Exosome Production to Attenuate NAFLD‐Associated Fibrosis

X Hou, S Yin, R Ren, S Liu, L Yong, Y Liu, Y Li… - …, 2021 - Wiley Online Library
Background ands Aims NAFLD is associated with elevation of many cytokines, particularly IL‐
6; however, the role of IL‐6 in NAFLD remains obscure. The aim of this study was to …

Treating inflammation to combat non-alcoholic fatty liver disease

L Wiering, F Tacke - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Non-alcoholic fatty liver disease (NAFLD) with its more progressive form non-alcoholic
steatohepatitis (NASH) has become the most common chronic liver disease, thereby …

[HTML][HTML] MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives

MY Hochreuter, M Dall, JT Treebak, R Barrès - Molecular metabolism, 2022 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) is a spectrum of disease ranging from
simple hepatic steatosis (NAFL) to non-alcoholic steatohepatitis (NASH) which may …

Neutrophils in liver diseases: pathogenesis and therapeutic targets

K Liu, FS Wang, R Xu - Cellular & molecular immunology, 2021 - nature.com
Previously, it was assumed that peripheral neutrophils are a homogeneous population that
displays antimicrobial functions. However, recent data have revealed that neutrophils are …

Neutrophil-to-hepatocyte communication via LDLR-dependent miR-223–enriched extracellular vesicle transfer ameliorates nonalcoholic steatohepatitis

Y He, RM Rodrigues, X Wang, W Seo… - The Journal of …, 2021 - Am Soc Clin Investig
Neutrophil infiltration around lipotoxic hepatocytes is a hallmark of nonalcoholic
steatohepatitis (NASH); however, how these 2 types of cells communicate remains obscure …

Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer

N Li, X Zhang, J Zhou, W Li, X Shu, Y Wu… - Advanced Drug Delivery …, 2022 - Elsevier
A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

Tumor-associated neutrophils in hepatocellular carcinoma pathogenesis, prognosis, and therapy

K Arvanitakis, I Mitroulis, G Germanidis - Cancers, 2021 - mdpi.com
Simple Summary Hepatocellular carcinoma is the most prevalent primary liver cancer,
accounting for> 80% of primary liver cancers worldwide. Inflammation has come to light as a …