Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …

Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …

Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells
and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB …

Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …

Invadopodia and podosomes are discrete, actin‐based molecular protrusions that form in
cancer cells and normal cells, respectively, in response to diverse signaling pathways and …

Osteoclasts are myeloid lineage-derived bone-resorbing cells of hematopoietic origin. They
differentiate from myeloid precursors through a complex regulation process where the …

Primary cancer modulates the bone microenvironment to sow the seeds of dormancy and
metastasis in tumor cells, leading to multiple organ metastasis and death. In this study, 3D …

The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but
its therapeutic potential in pathological bone loss remains unexplored. Here, we report that …

Therapeutic resistance represents a major cause of death for most lethal cancers. However,
the underlying mechanisms of such resistance have remained unclear. The polyploid cells …

Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and
repair of our bones are formed from bone marrow myeloid progenitor cells by a complex …