Matrix metalloproteinases shape the tumor microenvironment in cancer progression
S Niland, AX Riscanevo, JA Eble - International journal of molecular …, 2021 - mdpi.com
Cancer progression with uncontrolled tumor growth, local invasion, and metastasis depends
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
largely on the proteolytic activity of numerous matrix metalloproteinases (MMPs), which …
Mechanisms and roles of podosomes and invadopodia
S Linder, P Cervero, R Eddy, J Condeelis - Nature Reviews Molecular …, 2023 - nature.com
Cell invasion into the surrounding extracellular matrix or across tissue boundaries and
endothelial barriers occurs in both physiological and pathological scenarios such as …
endothelial barriers occurs in both physiological and pathological scenarios such as …
[HTML][HTML] Current understanding of RANK signaling in osteoclast differentiation and maturation
JH Park, NK Lee, SY Lee - Molecules and cells, 2017 - Elsevier
Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells
and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB …
and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB …
Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states
Muscle stem cells (MuSCs) are essential for tissue homeostasis and regeneration, but the
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …
potential contribution of MuSC morphology to in vivo function remains unknown. Here, we …
Invadosomes are coming: new insights into function and disease relevance
EK Paterson, SA Courtneidge - The FEBS journal, 2018 - Wiley Online Library
Invadopodia and podosomes are discrete, actin‐based molecular protrusions that form in
cancer cells and normal cells, respectively, in response to diverse signaling pathways and …
cancer cells and normal cells, respectively, in response to diverse signaling pathways and …
Osteoclast signal transduction during bone metastasis formation
Osteoclasts are myeloid lineage-derived bone-resorbing cells of hematopoietic origin. They
differentiate from myeloid precursors through a complex regulation process where the …
differentiate from myeloid precursors through a complex regulation process where the …
Premetastatic Niche Mimicking Bone‐On‐A‐Chip: A Microfluidic Platform to Study Bone Metastasis in Cancer Patients
X Ji, HP Bei, G Zhong, H Shao, X He, X Qian, Y Zhang… - Small, 2023 - Wiley Online Library
Primary cancer modulates the bone microenvironment to sow the seeds of dormancy and
metastasis in tumor cells, leading to multiple organ metastasis and death. In this study, 3D …
metastasis in tumor cells, leading to multiple organ metastasis and death. In this study, 3D …
Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss
X Li, L Wang, B Huang, Y Gu, Y Luo, X Zhi, Y Hu… - Science …, 2020 - science.org
The actin-bundling protein L-plastin (LPL) mediates the resorption activity of osteoclasts, but
its therapeutic potential in pathological bone loss remains unexplored. Here, we report that …
its therapeutic potential in pathological bone loss remains unexplored. Here, we report that …
[HTML][HTML] Human cell polyploidization: The good and the evil
J Zhang, Q Qiao, H Xu, R Zhou, X Liu - Seminars in cancer biology, 2022 - Elsevier
Therapeutic resistance represents a major cause of death for most lethal cancers. However,
the underlying mechanisms of such resistance have remained unclear. The polyploid cells …
the underlying mechanisms of such resistance have remained unclear. The polyploid cells …
Cell-surface phosphatidylserine regulates osteoclast precursor fusion
SK Verma, E Leikina, K Melikov, C Gebert… - Journal of Biological …, 2018 - ASBMB
Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and
repair of our bones are formed from bone marrow myeloid progenitor cells by a complex …
repair of our bones are formed from bone marrow myeloid progenitor cells by a complex …