The mammalian hippocampus is important for normal memory function, particularly memory
for places and events. Place cells, neurons within the hippocampus that have spatial …

Highlights•Experimental advances allow us to see long-term drift in neural
representations.•Drift challenges classical notions of receptive fields and engrams.•Drift is …

The hippocampus plays a critical role in goal-directed navigation. Across different
environments, however, hippocampal maps are randomized, making it unclear how goal …

The incorporation of new information into the hippocampal network is likely to be
constrained by its innate architecture and internally generated activity patterns. However, the …

During our daily life, we depend on memories of past experiences to plan future behaviour.
These memories are represented by the activity of specific neuronal groups or 'engrams' …

Spatial memories that can last a lifetime are thought to be encoded during 'online'periods of
exploration and subsequently consolidated into stable cognitive maps through their …

In mammals, the selective transformation of transient experience into stored memory occurs
in the hippocampus, which develops representations of specific events in the context in …

An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …

Recurrent excitatory connections in hippocampal regions CA3 and CA2 are thought to play
a key role in the generation of sharp-wave ripples (SWRs), electrophysiological oscillations …

The brain stores and recalls memories through a set of neurons, termed engram cells.
However, it is unclear how these cells are organized to constitute a corresponding memory …