Computational methods for transcriptome annotation and quantification using RNA-seq
High-throughput RNA sequencing (RNA-seq) promises a comprehensive picture of the
transcriptome, allowing for the complete annotation and quantification of all genes and their …
transcriptome, allowing for the complete annotation and quantification of all genes and their …
Advanced applications of RNA sequencing and challenges
Next-generation sequencing technologies have revolutionarily advanced sequence-based
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …
research with the advantages of high-throughput, high-sensitivity, and high-speed. RNA-seq …
Integrating proteomics and transcriptomics for systematic combinatorial chimeric antigen receptor therapy of AML
Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes
in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute …
in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute …
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
C Simon, J Chagraoui, J Krosl, P Gendron… - Genes & …, 2012 - genesdev.cshlp.org
In this study, we show the high frequency of spontaneous γδ T-cell leukemia (T-ALL)
occurrence in mice with biallelic deletion of enhancer of zeste homolog 2 (Ezh2). Tumor …
occurrence in mice with biallelic deletion of enhancer of zeste homolog 2 (Ezh2). Tumor …
S100A9 induces differentiation of acute myeloid leukemia cells through TLR4
M Laouedj, MR Tardif, L Gil, MA Raquil… - Blood, The Journal …, 2017 - ashpublications.org
Abstract S100A8 and S100A9 are calcium-binding proteins predominantly expressed by
neutrophils and monocytes and play key roles in both normal and pathological inflammation …
neutrophils and monocytes and play key roles in both normal and pathological inflammation …
[HTML][HTML] Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in acute myeloid leukemia
S Mohr, C Doebele, F Comoglio, T Berg, J Beck… - Cancer cell, 2017 - cell.com
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene
overexpression but is currently considered undruggable. We therefore investigated whether …
overexpression but is currently considered undruggable. We therefore investigated whether …
Evaluation of the coverage and depth of transcriptome by RNA-Seq in chickens
Background RNA-Seq is the recently developed high-throughput sequencing technology for
profiling the entire transcriptome in any organism. It has several major advantages over …
profiling the entire transcriptome in any organism. It has several major advantages over …
Molecular ontogeny of donor-derived follicular lymphomas occurring after hematopoietic cell transplantation
The relative timing of genetic alterations that contribute to follicular lymphoma remains
unknown. We analyzed a donor–recipient pair who both developed grade 2/3A follicular …
unknown. We analyzed a donor–recipient pair who both developed grade 2/3A follicular …
Rab25 is a tumor suppressor gene with antiangiogenic and anti-invasive activities in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC), the major histologic subtype of esophageal
cancer, is a devastating disease characterized by distinctly high incidences and mortality …
cancer, is a devastating disease characterized by distinctly high incidences and mortality …
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance
M Buscarlet, V Krasteva, L Ho, C Simon… - Blood, The Journal …, 2014 - ashpublications.org
In mammals, combinatorial assembly of alternative families of subunits confers functional
specificity to adenosine triphosphate (ATP)-dependent SWI/SNF-like Brg/Brm-associated …
specificity to adenosine triphosphate (ATP)-dependent SWI/SNF-like Brg/Brm-associated …