The public view on antibiotics as reliable medicines changed when reports about “resistant
superbugs” appeared in the news. While reasons for this resistance development are easily …

Drug-resistance dissemination by horizontal gene transfer remains poorly understood at the
cellular scale. Using live-cell microscopy, we reveal the dynamics of resistance acquisition …

Natural scaffolds remain an important basis for drug development. Therefore, approaches to
natural bioactive compound discovery attract significant attention. In this account, we …

Growing resistance toward ribosome-targeting macrolide antibiotics has limited their clinical
utility and urged the search for superior compounds. Macrolones are synthetic macrolide …

Endophytic actinobacteria are one of the important pharmaceutical resources and well
known for producing different types of bioactive substances. Nevertheless, detection of the …

The increase in multi-drug resistant pathogenic bacteria is making our current arsenal of
clinically used antibiotics obsolete, highlighting the urgent need for new lead compounds …

The antimicrobial resistance crisis along with challenges of antimicrobial discovery revealed
the vital necessity to develop new antibiotics. Many of the animal proline-rich antimicrobial …

Since the discovery of streptomycin, actinomycetes have been a useful source for new
antibiotics, but there have been diminishing rates of new finds since the 1960s. The …

Ribosome-synthesized post-translationally modified peptides (RiPPs) represent a rapidly
expanding class of natural products with various biological activities. Linear azol (in) e …

Whereas screening of the small-molecule metabolites produced by most cultivatable
microorganisms often results in the rediscovery of known compounds, genome-mining …