Major achievements in bone research have always relied on animal models and in vitro
systems derived from patient and animal material. However, the use of animals in research …

Convergent extension in the amphibian, Xenopus laevis - ScienceDirect Skip to main
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Morphogenesis is governed by the interplay of molecular signals and mechanical forces
across multiple length scales. The last decade has seen tremendous advances in our …

Convergent extension (CE) is an evolutionarily conserved collective cell movement that
elongates several organ systems during development. Studies have revealed two distinct …

Gastruloids have emerged as highly useful in vitro models of mammalian gastrulation. One
of the most striking features of 3D gastruloids is their elongation, which mimics the extension …

Multicellular aggregates are known to exhibit liquid-like properties. The fusion process of
two cell aggregates is commonly studied as the coalescence of two viscous drops. However …

Simulating morphogenesis of both mesenchyme and epithelium has typically required
complex and computationally expensive models. To meet this challenge, we developed ya …

Early limb bud development has been of considerable interest for the study of embryological
development and especially morphogenesis. The focus has long been on biochemical …

Despite continual renewal and damages, a multicellular organism is able to maintain its
complex morphology. How is this stability compatible with the complexity and diversity of …

Filopodia are finger-like actin-rich protrusions that extend from the cell surface and are
important for cell–cell communication and pathogen internalization. The small size and …