Tendon is a crucial component of the musculoskeletal system. Tendons connect muscle to
bone and transmit forces to produce motion. Chronic and acute tendon injuries are very …

Tendon injuries are common and can dramatically impair patient mobility and productivity,
resulting in a significant socioeconomic burden and reduced quality of life. Because the …

Tendon injuries cause prolonged disability and never recover completely. Current
mechanistic understanding of tendon regeneration is limited. Here, we use single-cell …

To date, the cell and molecular mechanisms regulating tendon healing are poorly
understood. Here, we establish a novel model of tendon regeneration using neonatal mice …

Tendon injuries are common and debilitating, with non-regenerative healing often resulting
in chronic disease. While there has been considerable progress in identifying the cellular …

Adult tendon tissue demonstrates a limited regenerative capacity, and the natural repair
process leaves fibrotic scar tissue with inferior mechanical properties. Surgical treatment is …

Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

Unlike during embryogenesis, the identity of tissue resident progenitor cells that contribute to
postnatal tendon growth and natural healing is poorly characterized. Therefore, we utilized …

Tendon injuries heal via a scar-mediated response, and there are no biological approaches
to promote more regenerative healing. Mouse flexor tendons heal through the formation of …

Studies of cell fate focus on specification, but little is known about maintenance of the
differentiated state. In this study, we find that the mouse tendon cell fate requires continuous …