The POLG gene encodes the mitochondrial DNA polymerase that is responsible for
replication of the mitochondrial genome. Mutations in POLG can cause early childhood …

Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …

Somatic cells accumulate genomic alterations with age; however, our understanding of
mitochondrial DNA (mtDNA) mosaicism remains limited. Here we investigated the genomes …

Cellular senescence refers to a stress response aiming to preserve cellular and, therefore,
organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic …

The ability to rapidly adapt cellular bioenergetic capabilities to meet rapidly changing
environmental conditions is mandatory for normal cellular function and for cancer …

Mitochondrial DNA (mtDNA) is believed to be highly vulnerable to age-associated damage
and mutagenesis by reactive oxygen species (ROS). However, somatic mtDNA mutations …

Mammalian mitochondria contain multiple copies of a circular, double-stranded DNA
genome and a dedicated DNA replication machinery is required for its maintenance. Many …

When describing the structure of the DNA double helix, Watson and Crick (1) wrote,“It has
not escaped our notice that the specific pairing we have postulated immediately suggests a …

In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …

Highly active antiretroviral therapy (HAART) regimes based on nucleoside reverse
transcriptase inhibitors (NRTIs) have revolutionized the treatment of AIDS in recent years …