Arsenic exposure: A public health problem leading to several cancers

I Palma-Lara, M Martínez-Castillo… - Regulatory Toxicology …, 2020 - Elsevier
Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements
in the earth's crust. Water is contaminated by arsenic through natural sources (underground …

Arsenic contamination of groundwater: a review of sources, prevalence, health risks, and strategies for mitigation

S Shankar, U Shanker, Shikha - The scientific world journal, 2014 - Wiley Online Library
Arsenic contamination of groundwater in different parts of the world is an outcome of natural
and/or anthropogenic sources, leading to adverse effects on human health and ecosystem …

Arsenic exposure and toxicology: a historical perspective

MF Hughes, BD Beck, Y Chen, AS Lewis… - Toxicological …, 2011 - academic.oup.com
The metalloid arsenic is a natural environmental contaminant to which humans are routinely
exposed in food, water, air, and soil. Arsenic has a long history of use as a homicidal agent …

Arsenic and selenium toxicity and their interactive effects in humans

HJ Sun, B Rathinasabapathi, B Wu, J Luo, LP Pu… - Environment …, 2014 - Elsevier
Abstract Arsenic (As) and selenium (Se) are unusual metalloids as they both induce and
cure cancer. They both cause carcinogenesis, pathology, cytotoxicity, and genotoxicity in …

Environmental chemical exposures and human epigenetics

L Hou, X Zhang, D Wang… - International journal of …, 2012 - academic.oup.com
Every year more than 13 million deaths worldwide are due to environmental pollutants, and
approximately 24% of diseases are caused by environmental exposures that might be …

Arsenic causing gallbladder cancer disease in Bihar

A Kumar, M Ali, V Raj, A Kumari, M Rachamalla… - Scientific reports, 2023 - nature.com
In recent times Gallbladder cancer (GBC) incidences increased many folds in India and are
being reported from arsenic hotspots identified in Bihar. The study aims to establish …

Aberrant epigenetic landscape in cancer: how cellular identity goes awry

M Berdasco, M Esteller - Developmental cell, 2010 - cell.com
Appropriate patterns of DNA methylation and histone modifications are required to assure
cell identity, and their deregulation can contribute to human diseases, such as cancer. Our …

Epigenetic gene regulation: linking early developmental environment to adult disease

DC Dolinoy, JR Weidman, RL Jirtle - Reproductive toxicology, 2007 - Elsevier
Traditional studies on the combined effects of genetics and the environment on individual
variation in disease susceptibility primarily focus on single nucleotide polymorphisms that …

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

JF Reichard, A Puga - Epigenomics, 2010 - Taylor & Francis
Arsenic is a nonmutagenic human carcinogen that induces tumors through unknown
mechanisms. A growing body of evidence suggests that its carcinogenicity results from …

An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis

X Ren, CM McHale, CF Skibola, AH Smith… - Environmental …, 2011 - ehp.niehs.nih.gov
Background Exposure to arsenic, an established human carcinogen, through consumption
of highly contaminated drinking water is a worldwide public health concern. Several …