Exploration of isoxazole analogs: Synthesis, COX inhibition, anticancer screening, 3D multicellular tumor spheroids, and molecular modeling
In this study, a new series of Isoxazole-carboxamide derivatives were synthesized and
characterized via HRMS, 1 H-, 13 C APT-NMR, and MicroED. The findings revealed that …
characterized via HRMS, 1 H-, 13 C APT-NMR, and MicroED. The findings revealed that …
1, 3-Thiazole Derivatives as a Promising Scaffold in Medicinal Chemistry: A Recent Overview
P Kushwaha, S Pandey - … -Inflammatory & Anti-Allergy Agents in …, 2023 - ingentaconnect.com
The thiazole ring is a unique heterocyclic motif among heterocyclic compounds. This five-
member ring with one nitrogen and one sulphur atom displays a wide array of …
member ring with one nitrogen and one sulphur atom displays a wide array of …
Discovery of new 2-(3-(naphthalen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl) thiazole derivatives with potential analgesic and anti-inflammatory activities: In vitro, in vivo and …
ER Mohammed, AH Abd-El-Fatah, AR Mohamed… - Bioorganic …, 2024 - Elsevier
Joining the global demand for the discovery of potent NSAIDs with minimized ulcerogenic
effect, new pyrazole clubbed thiazole derivatives 5a-o were designed and synthesized. The …
effect, new pyrazole clubbed thiazole derivatives 5a-o were designed and synthesized. The …
HPLC-UV method for the quantification of a novel indole-thiazole derivative (CS08) in nanoparticles
JCS Soares, IDL Cavalcanti, IJ da Cruz-Filho… - Microchemical …, 2024 - Elsevier
Background Validation of an analytical method for the quantification of a drug candidate
molecule is the first step. The quantification method is fundamental in the pharmaceutical …
molecule is the first step. The quantification method is fundamental in the pharmaceutical …
[HTML][HTML] Unveiling Anticancer Potential of COX-2 and 5-LOX Inhibitors: Cytotoxicity, Radiosensitization Potential and Antimigratory Activity against Colorectal and …
J Bošković, V Dobričić, O Keta, L Korićanac, J Žakula… - Pharmaceutics, 2024 - mdpi.com
Apart from cytotoxicity, inhibitors of the COX-2 enzyme have demonstrated additional effects
important for cancer treatment (such as radiosensitization of tumor cells and cell …
important for cancer treatment (such as radiosensitization of tumor cells and cell …
[HTML][HTML] 6-Bromo quinazoline derivatives as cytotoxic agents: design, synthesis, molecular docking and MD simulation
Based on unselectively, several side effects and drug resistance of available anticancer
agents, the development and research for novel anticancer agents is necessary. In this …
agents, the development and research for novel anticancer agents is necessary. In this …
[PDF][PDF] Синтез та біологічна активність похідних фуранкарбонових кислот
Ю Матійчук - Annals of pharmaceutical faculty. April, 2021 - library.dmed.org.ua
АНОТАЦІЯ Матійчук ЮЕ Синтез та біологічна активність похідних фуранкарбонових
кислот.–Кваліфікаційна наукова праця на правах рукопису. Дисертація на здобуття …
кислот.–Кваліфікаційна наукова праця на правах рукопису. Дисертація на здобуття …