Hypervalent iodine (III) compounds have found wide application in modern organic
chemistry as environmentally friendly reagents and catalysts. Hypervalent iodine reagents …

The site-selective modification of amino acids, peptides, and proteins has always been an
intensive topic in organic synthesis, medicinal chemistry, and chemical biology due to the …

Cysteine chemoproteomics provides proteome-wide portraits of the ligandability or potential"
druggability" for thousands of cysteine residues. Consequently, these studies are facilitating …

Covalent chemistry is a versatile approach for expanding the ligandability of the human
proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by …

Cysteine conjugation is an important tool in protein research and relies on fast, mild and
chemoselective reactions. Cysteinyl thiols can either be modified with prefunctionalized …

The evolving use of covalent ligands as chemical probes and therapeutic agents could
greatly benefit from an expanded array of cysteine-reactive electrophiles for efficient and …

Cysteine has been exploited as the binding site of covalent drugs. Its high sensitivity to
oxidation is also important for regulating cellular processes. To identify new ligandable …

Covalent drug discovery has undergone a resurgence over the past two decades and
reactive cysteine profiling has emerged in parallel as a platform for ligand discovery through …

Radiotherapy is widely used as an indispensable treatment option for cervical cancer
patients. However, radioresistance always occurs and has become a big obstacle to …

Peptide and protein postmodification have gained significant attention due to their extensive
impact on biomolecule engineering and drug discovery, of which cysteine‐specific …