The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in
embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin …

Bone regeneration repairs bone tissue lost due to trauma, fractures, and tumors, or absent
due to congenital disorders. The extracellular matrix (ECM) is an intricate dynamic bio …

Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Single-cell RNA sequencing (scRNA-seq) enables specific profiling of cell populations at
single-cell resolution. The osteoimmunology microenvironment in the occurrence and …

Critical‐sized bone defects, especially for irregular shapes, remain a significant challenge in
orthopedics. Although various biomaterials are developed for bone regeneration, their …

Objectives Synovium is acutely affected following joint trauma and contributes to post-
traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and …

Therapeutics targeting osteoclasts are commonly used treatments for bone metastasis;
however, whether and how osteoclasts regulate premetastatic niche and bone tropism are …

Bone regulates its mass and quality in response to diverse mechanical, hormonal, and local
signals. The bone anabolic or catabolic responses to these signals are often received by …

With increasing age of the population, countries across the globe are facing a substantial
increase in osteoporotic fractures. Genetic association signals for fractures have been …