[HTML][HTML] Role of H3K4 monomethylation in gene regulation
Highlights•H3K4 monomethylation (H3K4me1) is a conserved histone mark.•H3K4me1 is
implicated in various regulatory stages of gene regulation.•Data supporting and opposing a …
implicated in various regulatory stages of gene regulation.•Data supporting and opposing a …
KMT2 family of H3K4 methyltransferases: enzymatic activity-dependent and-independent functions
Abstract Histone-lysine N-methyltransferase 2 (KMT2) methyltransferases play critical roles
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …
in gene regulation, cell differentiation, animal development, and human diseases. KMT2 …
[HTML][HTML] Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes
H3K36me2, is essential for mammalian development and is frequently dysregulated in …
H3K36me2, is essential for mammalian development and is frequently dysregulated in …
H3K4me1 facilitates promoter-enhancer interactions and gene activation during embryonic stem cell differentiation
Histone H3 lysine 4 mono-methylation (H3K4me1) marks poised or active enhancers.
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …
KMT2C (MLL3) and KMT2D (MLL4) catalyze H3K4me1, but their histone methyltransferase …
Activation, decommissioning, and dememorization: enhancers in a life cycle
Spatiotemporal regulation of cell type-specific gene expression is essential to convert a
zygote into a complex organism that contains hundreds of distinct cell types. A class of cis …
zygote into a complex organism that contains hundreds of distinct cell types. A class of cis …
Origin, fate and function of extraembryonic tissues during mammalian development
S Thowfeequ, CW Hanna, S Srinivas - Nature Reviews Molecular Cell …, 2024 - nature.com
Extraembryonic tissues have pivotal roles in morphogenesis and patterning of the early
mammalian embryo. Developmental programmes mediated through signalling pathways …
mammalian embryo. Developmental programmes mediated through signalling pathways …
ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers
The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3
are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and …
are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and …
Functional Roles of H3K4 Methylation in Transcriptional Regulation
H Yu, BJ Lesch - Molecular and Cellular Biology, 2024 - Taylor & Francis
Abstract Histone 3 lysine 4 methylation (H3K4me) is a highly evolutionary conserved
chromatin modification associated with active transcription, and its three methylation states …
chromatin modification associated with active transcription, and its three methylation states …
Regulation of T helper cell differentiation by the interplay between histone modification and chromatin interaction
The development and function of the immune system are controlled by temporospatial gene
expression programs, which are regulated by cis-regulatory elements, chromatin structure …
expression programs, which are regulated by cis-regulatory elements, chromatin structure …
Nuclear control of vascular smooth muscle cell plasticity during vascular remodeling
Control of vascular smooth muscle cell (SMC) gene expression is an essential process for
establishing and maintaining lineage identity, contractility, and plasticity. Most mechanisms …
establishing and maintaining lineage identity, contractility, and plasticity. Most mechanisms …