The contribution of nerves to the pathogenesis of malignancies has emerged as an
important component of the tumour microenvironment. Recent studies have shown that …

Convincing evidence has repeatedly shown that new neurons are produced in the
mammalian brain into adulthood. Adult neurogenesis has been best described in the …

A large population of neural stem/precursor cells (NSCs) persists in the ventricular–
subventricular zone (V-SVZ) located in the walls of the lateral brain ventricles. V-SVZ NSCs …

Autonomic nerve fibres in the tumour microenvironment regulate cancer initiation and
dissemination, but how nerves emerge in tumours is currently unknown. Here we show that …

Folding of the cerebral cortex is a fundamental milestone of mammalian brain evolution and
is associated with dramatic increases in size and complexity. New animal models, genetic …

One of the most prominent features of the human brain is the fabulous size of the cerebral
cortex and its intricate folding. Cortical folding takes place during embryonic development …

During development of the central nervous system, expression of the microtubule binding
protein doublecortin (DCX) is associated with migration of neuroblasts. In addition to this …

Vascular endothelial growth factor (VEGF) is an angiogenic protein with neurotrophic and
neuroprotective effects. Because VEGF promotes the proliferation of vascular endothelial …

The discovery that the adult mammalian brain creates new neurons from pools of stemlike
cells was a breakthrough in neuroscience. Interestingly, this particular new form of structural …

Because neurogenesis persists in the adult mammalian brain and can be regulated by
physiological and pathological events, we investigated its possible involvement in the …