Recent years have been transformational in regard to the perception of the health risks and
benefits of cannabis with increased acceptance of use. This has unintended …

The broad-based legalization of cannabis use has created a strong need to understand its
impact on human health and behavior. The risks that may be associated with cannabis use …

Decriminalization, medicalization, and legalization of cannabis use by a majority of US
states over the past 25 years have dramatically shifted societal perceptions and use patterns …

Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Studies using animal models of adolescent exposure to alcohol, nicotine, cannabinoids, and
the stimulants cocaine, 3, 4-methylenedioxymethampethamine and methamphetamine have …

The hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in
executive and emotional functions. Neurophysiological studies have begun to unveil the …

Adolescence is the transitional period between childhood and adulthood, during which
extensive brain development occurs. Since this period also overlaps with the initiation of …

Substance use in adolescence is a known risk factor for the development of neuropsychiatric
and substance use disorders in adulthood. This is in part due to the fact that critical aspects …

Cannabis use during the critical neurodevelopmental period of adolescence, may lead to
brain structural, functional, and histological alterations that may underpin some of the longer …

Chronic adolescent marijuana use has been linked to the later development of psychiatric
diseases such as schizophrenia. GABAergic hypofunction in the prefrontal cortex (PFC) is a …