GABA tone regulation and its cognitive functions in the brain
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …
Hippocampal GABAergic inhibitory interneurons
KA Pelkey, R Chittajallu, MT Craig… - Physiological …, 2017 - journals.physiology.org
In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …
of the total neuronal population; however, their remarkable anatomical and physiological …
[HTML][HTML] GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease
J Jiménez-Balado, TS Eich - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic)
system in age-related episodic memory impairments in humans, with a particular focus on …
system in age-related episodic memory impairments in humans, with a particular focus on …
SLC6 neurotransmitter transporters: structure, function, and regulation
AS Kristensen, J Andersen, TN Jørgensen… - Pharmacological …, 2011 - ASPET
The neurotransmitter transporters (NTTs) belonging to the solute carrier 6 (SLC6) gene
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
family (also referred to as the neurotransmitter-sodium-symporter family or Na+/Cl …
Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
The proper functioning of the adult mammalian brain relies on the orchestrated regulation of
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …
GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations
Y Ben-Ari, JL Gaiarsa, R Tyzio… - Physiological …, 2007 - journals.physiology.org
Developing networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …
operate via thousands of synapses. This review deals with some of these rules and in …
Towards a better understanding of GABAergic remodeling in Alzheimer's disease
K Govindpani, B Calvo-Flores Guzmán… - International journal of …, 2017 - mdpi.com
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …
In the past, there has been a major research drive focused on the dysfunction of the …
Tonic inhibition in dentate gyrus impairs long-term potentiation and memory in an Alzheimer's disease model
Amyloid plaques and tau tangles are common pathological hallmarks for Alzheimer's
disease (AD); however, reducing Aβ production failed to relieve the symptoms of AD …
disease (AD); however, reducing Aβ production failed to relieve the symptoms of AD …
Electrophysiology of ionotropic GABA receptors
E Sallard, D Letourneur, P Legendre - Cellular and Molecular Life …, 2021 - Springer
GABAA receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …
main inhibitory neurotransmitter in vertebrates. In this review, we discuss the major and …
Extrasynaptic GABAA receptors: form, pharmacology, and function
D Belelli, NL Harrison, J Maguire… - Journal of …, 2009 - Soc Neuroscience
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and
GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed …
GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed …