Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Pharmacological ascorbate has been proposed as a potential anti-cancer agent when
combined with radiation and chemotherapy. The anti-cancer effects of ascorbate are …

First isolated in the early 1960s, doxorubicin (DOX) remains among the most effective
anticancer drug ever developed. However, this drug has proven to be a double-edged …

Besides the cytochrome c pathway, plant mitochondria have an alternative respiratory
pathway that is comprised of a single homodimeric protein, alternative oxidase (AOX) …

Ascorbate is a cofactor in numerous metabolic reactions. Humans cannot synthesize
ascorbate owing to inactivation of the gene encoding the enzyme l-gulono-γ-lactone …

The transferrin receptor is a membrane glycoprotein whose only clearly defined function is to
mediate cellular uptake of iron from a plasma glycoprotein, transferrin. Iron uptake from …

Iron and oxygen share a delicate partnership since both are indispensable for survival, but if
the partnership becomes inadequate, this may rapidly terminate life. Virtually all cell …

Iron accumulation and neuroinflammation are pathological conditions found in several
neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease …

Iron is required for normal cell growth and proliferation. However, excess iron is potentially
harmful, as it can catalyse the formation of toxic reactive oxygen species (ROS) via Fenton …

▪ Abstract Mammalian iron homeostasis is maintained through the concerted action of
sensory and regulatory networks that modulate the expression of proteins of iron metabolism …