▪ Abstract In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the
ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built …

Protein degradation is a necessity for many reasons: Homeostasis must be maintained while
cellular structures are continually rebuilt, in particular during development or in response to …

ABSTRACT CORUM is a database that provides a manually curated repository of
experimentally characterized protein complexes from mammalian organisms, mainly human …

Since the late 1970s, determining the phylogenetic relationships among the contemporary
domains of life, the Archaea (archaebacteria), Bacteria (eubacteria), and Eucarya …

Over the past decade there has been considerable progress in understanding how MHC
class I-presented peptides are generated. The emerging theme is that the immune system …

One of the most precisely regulated processes in living cells is intracellular protein
degradation. The main component of the degradation machinery is the 20S proteasome …

Proteins are the main executers of genetic functions. Within a cell, the level of a protein is
determined by its synthesis and turnover rates. In the last three decades, it has become …

Among the hundreds of proteases characterized so far, most of which are monomeric or
dimeric, there is a small group that form compartments through self-association and that …

In 26S proteasomes,“19S cap complexes” associate with either one or both ends of the
barrel-shaped 20S core complex. These regulatory complexes which comprise about 20 …

Mycobacterium tuberculosis uses a proteasome system that is analogous to the eukaryotic
ubiquitin-proteasome pathway and is required for pathogenesis. However, the bacterial …