Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease

AG White, E Elias, A Orozco, SA Robinson… - International Journal of …, 2024 - mdpi.com
The brain is the central organ of adaptation to stress because it perceives and determines
threats that induce behavioral, physiological, and molecular responses. In humans, chronic …

Effect of natural adenylcyclase/cAMP/CREB signalling activator forskolin against intra-striatal 6-OHDA-lesioned Parkinson's rats: preventing mitochondrial, motor and …

M Alharbi, A Alshammari, G Kaur, S Kalra, S Mehan… - Molecules, 2022 - mdpi.com
Parkinson's disease (PD) is characterised by dopaminergic neuronal loss in the brain area.
PD is a complex disease that deteriorates patients' motor and non-motor functions. In …

Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats

V Agarwal, AS Kaushik, R Chaudhary… - Naunyn-Schmiedeberg's …, 2024 - Springer
Chronically stressed patients often have low vagal tone and increased levels of
proinflammatory cytokines, which increase their risk for developing cardiac dysfunction …

Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways

M Rehman, R Chaudhary, S Rajput, V Agarwal… - Physiology & …, 2023 - Elsevier
Chronic stress is a major risk factor for various diseases, including cardiovascular diseases
(CVDs). Chronic stress enhances the release of pro-inflammatory cytokines like IL-1β, IL-6 …

Inflammation as a shared mechanism of chronic stress related disorders with potential novel therapeutic targets

A Gupta, V Agarwal - Naunyn-Schmiedeberg's Archives of Pharmacology, 2024 - Springer
Stress is a subjective experience that varies across individuals depending on their
sensitivity, resilience, and length of exposure to stressors. Stress may be categorised as …

Synthesis and appraisal of dalbergin-loaded PLGA nanoparticles modified with galactose against hepatocellular carcinoma: In-vitro, pharmacokinetic, and in-silico …

AK Gautam, P Kumar, B Maity, G Routholla… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignancy which affects a substantial
number of individuals all over the globe. It is the third primary cause of death among persons …

Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis

R Chaudhary, A Prasad, V Agarwal, M Rehman… - International …, 2023 - Elsevier
The global incidence of autoimmune diseases is on the rise, and many healthcare
professionals believe that chronic stress plays a prominent role in both the aggravation and …

Sliding Microneedle-Lateral flow immunoassay strip device for highly sensitive biomarker detection in interstitial fluid

GR Yang, W Kim, JH Jung - Biosensors and Bioelectronics, 2024 - Elsevier
Diabetes is a chronic disease with significant complications, necessitating regular treatment
and checkups, which can be costly and time-consuming for patients. To address this, we …

Uncovering the Cardioprotective Potential of Diacerein in Doxorubicin Cardiotoxicity: Mitigating Ferritinophagy-Mediated Ferroptosis via Upregulating NRF2/SLC7A11 …

RM El-Gohary, AH Okasha, AH Abd El-Azeem… - Antioxidants, 2024 - mdpi.com
Doxorubicin (DOX)-induced cardiotoxicity (DIC) is a life-threatening clinical issue with
limited preventive approaches, posing a substantial challenge to cancer survivors. The …

Cardioprotective role of diacerein in diabetic cardiomyopathy via modulation of inflammasome/caspase1/interleukin1β pathway in juvenile rats

MMM Refaie, HH Mohammed… - Naunyn-Schmiedeberg's …, 2024 - Springer
Diabetes mellitus is a common metabolic disorder affecting different body organs; one of its
serious complications is diabetic cardiomyopathy (DCM). Thus, finding more …