Host-directed immunotherapy of viral and bacterial infections: past, present and future
The advent of COVID-19 and the persistent threat of infectious diseases such as
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
tuberculosis, malaria, influenza and HIV/AIDS remind us of the marked impact that infections …
Incipient and subclinical tuberculosis: a clinical review of early stages and progression of infection
Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …
limited understanding of its clinical pathogenic spectrum of infection and disease …
The immunoregulatory landscape of human tuberculosis granulomas
Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …
infected tissues, the architecture and composition of which are thought to affect disease …
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …
Tuberculosis: advances and challenges in development of new diagnostics and biomarkers
Tuberculosis remains the leading cause of death from an infectious disease worldwide.
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …
Early and accurate diagnosis and detection of drug-sensitive and drug-resistant tuberculosis …
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques
K Dijkman, CC Sombroek, RAW Vervenne… - Nature medicine, 2019 - nature.com
Tuberculosis (TB) remains the deadliest infectious disease, and the widely used Bacillus
Calmette–Guérin (BCG) vaccine fails to curb the epidemic. An improved vaccination strategy …
Calmette–Guérin (BCG) vaccine fails to curb the epidemic. An improved vaccination strategy …
The Innate Immune Response to Mycobacterium tuberculosis Infection
MM Ravesloot-Chávez, E Van Dis… - Annual review of …, 2021 - annualreviews.org
Infection with Mycobacterium tuberculosis causes> 1.5 million deaths worldwide annually.
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …
Innate immune cells are the first to encounter M. tuberculosis, and their response dictates …
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
R Roy Chowdhury, F Vallania, Q Yang… - Nature, 2018 - nature.com
Most infections with Mycobacterium tuberculosis (Mtb) manifest as a clinically asymptomatic,
contained state, known as latent tuberculosis infection, that affects approximately one …
contained state, known as latent tuberculosis infection, that affects approximately one …
Airway T cells are a correlate of iv Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Summary Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis
(Mtb) vaccine, provides limited durable protection when administered intradermally …
(Mtb) vaccine, provides limited durable protection when administered intradermally …
Four-gene pan-African blood signature predicts progression to tuberculosis
S Suliman, EG Thompson, J Sutherland… - American journal of …, 2018 - atsjournals.org
Rationale: Contacts of patients with tuberculosis (TB) constitute an important target
population for preventive measures because they are at high risk of infection with …
population for preventive measures because they are at high risk of infection with …