MicroRNAs as the critical regulators of forkhead box protein family in pancreatic, thyroid, and liver cancers

I Akhlaghipour, A Fanoodi, AS Zangouei… - Biochemical …, 2023 - Springer
The metabolism of human body is mainly regulated by the pancreas, liver, and thyroid using
the hormones or exocrine secretions that affect the metabolic processes from food digestion …

Members of FOX family could be drug targets of cancers

J Wang, W Li, Y Zhao, DE Kang, W Fu, X Zheng… - Pharmacology & …, 2018 - Elsevier
FOX families play important roles in biological processes, including metabolism,
development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here …

Identification of a 6-gene signature predicting prognosis for colorectal cancer

S Zuo, G Dai, X Ren - Cancer cell international, 2019 - Springer
Background An accurate and robust gene signature is of the utmost importance in assisting
oncologists to make a more accurate evaluation in clinical practice. In our study, we …

MicroRNA-92a-1–5p increases CDX2 by targeting FOXD1 in bile acids-induced gastric intestinal metaplasia

T Li, H Guo, H Li, Y Jiang, K Zhuang, C Lei, J Wu… - Gut, 2019 - gut.bmj.com
Background and aims Gastric intestinal metaplasia (IM) is common in the gastric epithelium
of patients with chronic atrophic gastritis. CDX2 activation in IM is driven by reflux of bile …

[HTML][HTML] Down-regulation of miR-30a-5p is associated with poor prognosis and promotes chemoresistance of gemcitabine in pancreatic ductal adenocarcinoma

L Zhou, S Jia, G Ding, M Zhang, W Yu, Z Wu… - Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract MicroRNA-30a-5p (miR-30a-5p) plays an important role in many biological and
pathological processes, and therefore has been studied extensively. However, its …

The multisystemic functions of FOXD1 in development and disease

P Quintero-Ronderos, P Laissue - Journal of Molecular Medicine, 2018 - Springer
Transcription factors (TFs) participate in a wide range of cellular processes due to their
inherent function as essential regulatory proteins. Their dysfunction has been linked to …

[HTML][HTML] FOXD1 is targeted by miR-30a-5p and miR-200a-5p and suppresses the proliferation of human ovarian carcinoma cells by promoting p21 expression in a p53 …

Y Wang, C Qiu, N Lu, Z Liu, C Jin… - International …, 2018 - spandidos-publications.com
High-grade serous ovarian carcinoma (HGSOC) accounts for the highest number of deaths
among patients with epithelial ovarian cancer. However, the molecular mechanisms …

[HTML][HTML] FOXD1 promotes cell growth and metastasis by activation of vimentin in NSCLC

D Li, S Fan, F Yu, X Zhu, Y Song, M Ye… - Cellular physiology and …, 2019 - karger.com
Background/Aims: Forkhead box D1 (FOXD1) has a well-established role in early embryonic
development and organogenesis and functions as an oncogene in several cancers …

LncRNA FOXD1‐AS1 acts as a potential oncogenic biomarker in glioma

YF Gao, JY Liu, XY Mao, ZW He, T Zhu… - CNS Neuroscience …, 2020 - Wiley Online Library
Aims Altered activities of long noncoding RNAs (lncRNAs) have been associated with
cancer development, and lncRNA FOXD1‐AS1 (FOXD1‐AS1) is the antisense transcript of …

FOXD1 and Gal-3 form a positive regulatory loop to regulate lung cancer aggressiveness

CH Li, YC Chang, M Hsiao, SM Liang - Cancers, 2019 - mdpi.com
Dysregulation of forkhead box D1 (FOXD1) is known to promote tumor progression;
however, its molecular mechanism of action is unclear. Based on microarray analysis, we …