Stem-cell-based embryo models for fundamental research and translation
Despite its importance, understanding the early phases of human development has been
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
limited by availability of human samples. The recent emergence of stem-cell-derived embryo …
[HTML][HTML] Mouse gastrulation: Coordination of tissue patterning, specification and diversification of cell fate
ES Bardot, AK Hadjantonakis - Mechanisms of development, 2020 - Elsevier
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …
during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and …
Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids
DA Turner, M Girgin, L Alonso-Crisostomo… - …, 2017 - journals.biologists.com
The establishment of the anteroposterior (AP) axis is a crucial step during animal embryo
development. In mammals, genetic studies have shown that this process relies on signals …
development. In mammals, genetic studies have shown that this process relies on signals …
NANOG and CDX2 pattern distinct subtypes of human mesoderm during exit from pluripotency
Mesoderm is induced at the primitive streak (PS) and patterns subsequently into
mesodermal subtypes and organ precursors. It is unclear whether mesoderm induction …
mesodermal subtypes and organ precursors. It is unclear whether mesoderm induction …
[HTML][HTML] Gastruloids generated without exogenous Wnt activation develop anterior neural tissues
When stimulated with a pulse from an exogenous WNT pathway activator, small aggregates
of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and …
of mouse embryonic stem cells (ESCs) can undergo embryo-like axial morphogenesis and …
Gastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering
Gastrulation is a fundamental and critical process of animal development whereby the mass
of cells that results from the proliferation of the zygote transforms itself into a recognizable …
of cells that results from the proliferation of the zygote transforms itself into a recognizable …
β-Catenin regulates primitive streak induction through collaborative interactions with SMAD2/SMAD3 and OCT4
NS Funa, KA Schachter, M Lerdrup, J Ekberg, K Hess… - Cell stem cell, 2015 - cell.com
Summary Canonical Wnt and Nodal signaling are both required for induction of the primitive
streak (PS), which guides organization of the early embryo. The Wnt effector β-catenin is …
streak (PS), which guides organization of the early embryo. The Wnt effector β-catenin is …
Endogenous WNT signals mediate BMP-induced and spontaneous differentiation of epiblast stem cells and human embryonic stem cells
Therapeutic application of human embryonic stem cells (hESCs) requires precise control
over their differentiation. However, spontaneous differentiation is prevalent, and growth …
over their differentiation. However, spontaneous differentiation is prevalent, and growth …
Stem-cell-based human and mouse embryo models
M Bao, J Cornwall-Scoones… - Current opinion in genetics …, 2022 - Elsevier
Synthetic embryology aims to develop embryo-like structures from stem cells to provide new
insight into early stages of mammalian development. Recent advances in synthetic …
insight into early stages of mammalian development. Recent advances in synthetic …
The dynamics of morphogenesis in the early mouse embryo
JA Rivera-Pérez… - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
Over the past two decades, our understanding of mouse development from implantation to
gastrulation has grown exponentially with an upsurge of genetic, molecular, cellular, and …
gastrulation has grown exponentially with an upsurge of genetic, molecular, cellular, and …