[HTML][HTML] Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …
single-cell technologies have revealed that these reactive microglia were with high spatial …
Microglia phenotypes in aging and neurodegenerative diseases
MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …
fundamental role in mediating the onset and progression of disease. Microglia, which …
Single-cell and spatial transcriptomics: deciphering brain complexity in health and disease
In the past decade, single-cell technologies have proliferated and improved from their
technically challenging beginnings to become common laboratory methods capable of …
technically challenging beginnings to become common laboratory methods capable of …
Early Alzheimer's disease pathology in human cortex involves transient cell states
Cellular perturbations underlying Alzheimer's disease (AD) are primarily studied in human
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
postmortem samples and model organisms. Here, we generated a single-nucleus atlas from …
Microglia mediated neuroinflammation in Parkinson's disease
S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …
Neuroinflammation: An astrocyte perspective
Astrocytes are abundant glial cells in the central nervous system (CNS) that play active roles
in health and disease. Recent technologies have uncovered the functional heterogeneity of …
in health and disease. Recent technologies have uncovered the functional heterogeneity of …
Mapping human adult hippocampal neurogenesis with single-cell transcriptomics: reconciling controversy or fueling the debate?
The notion of exploiting the regenerative potential of the human brain in physiological aging
or neurological diseases represents a particularly attractive alternative to conventional …
or neurological diseases represents a particularly attractive alternative to conventional …
Border-associated macrophages mediate the neuroinflammatory response in an alpha-synuclein model of Parkinson disease
AM Schonhoff, DA Figge, GP Williams… - Nature …, 2023 - nature.com
Dopaminergic cell loss due to the accumulation of α-syn is a core feature of the
pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein …
pathogenesis of Parkinson disease. Neuroinflammation specifically induced by α-synuclein …
Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases
The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …