Studies of nuclear architecture using chromosome conformation capture methods have
provided a detailed view of how chromatin folds in the 3D nuclear space. New variants of …

The 3D genome organization and its dynamic modulate genome function, playing a pivotal
role in cell differentiation and development. CTCF and cohesin, acting as the core …

Biophysical stimulation regulates stem cell functions, including proliferation and
differentiation. Matrix nanotopography and external forces, such as electromagnetic fields …

Abstract CCCTC-binding factor (CTCF), a ubiquitously expressed and highly conserved
protein, is known to play a critical role in chromatin structure. Post-translational modifications …

Protein kinases constitute a rich pool of biomarkers and therapeutic targets of tremendous
diseases including cancer. However, sensing kinase activity in vivo while implementing …

The emergence and progression of cancers is accompanied by a dysregulation of
transcriptional programs. The three-dimensional (3D) organization of the human genome …

CCCTC-binding factor (CTCF) is a multifunctional zinc-finger protein that is conserved in
metazoan species. CTCF is consistently found to play an important role in many diverse …

The Hippo pathway is a dynamic cellular signalling nexus that regulates differentiation and
controls cell proliferation and death. If the Hippo pathway is not precisely regulated, the …

The cancer epigenome has been studied in cells cultured in two-dimensional (2D)
monolayers, but recent studies highlight the impact of the extracellular matrix and the three …

Gastrulation is a critical stage in embryonic development during which the germ layers are
established. Advances in sequencing technologies led to the identification of gene …