Organodiselenides: Organic catalysis and drug design learning from glutathione peroxidase

MD Tiezza, G Ribaudo, L Orian - Current Organic Chemistry, 2019 - ingentaconnect.com
Organodiselenides are an important class of compounds characterized by the presence of
two adjacent covalently bonded selenium nuclei. Among them, diaryldiselenides and their …

Selenium‐NMR Spectroscopy in Organic Synthesis: From Structural Characterization Toward New Investigations

MS Silva, D Alves, D Hartwig, RG Jacob… - Asian Journal of …, 2021 - Wiley Online Library
This review article deals with organic synthesis from the perspective of selenium‐77 nuclear
magnetic resonance (NMR) spectroscopy. Different types of organic reactions are briefly …

Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)

FB Omage, A Madabeni, AR Tucci… - Journal of Chemical …, 2023 - ACS Publications
The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main
protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral …

Development of a high-performance proton exchange membrane: from structural optimization to quantity production

W Yu, Z Ge, K Zhang, X Liang, X Ge… - Industrial & …, 2022 - ACS Publications
Quantity production of low-cost and high-performance proton exchange membranes (PEMs)
used in hydrogen fuel cells is the centerpiece step toward the hydrogen future. Herein, we …

Mechanistic Insight into the Oxidation of Organic Phenylselenides by H2O2

G Ribaudo, M Bellanda, I Menegazzo… - … A European Journal, 2017 - Wiley Online Library
The oxidation of organic phenylselenides by H2O2 is investigated in model compounds,
namely, n‐butyl phenyl selenide (PhSe (nBu)), bis (phenylselanyl) methane (PhSeMeSePh) …

Role of the chalcogen (S, Se, Te) in the oxidation mechanism of the glutathione peroxidase active site

M Bortoli, M Torsello, FM Bickelhaupt… - ChemPhysChem, 2017 - Wiley Online Library
The oxidation by H2O2 of the human phospholipid hydroperoxide glutathione peroxidase
(GPx4), used as a model peroxidase selenoenzyme, as well as that of its cysteine (Cys) and …

Differential molecular mechanisms of substrate recognition by selenium methyltransferases, INMT and TPMT, in selenium detoxification and excretion

Y Fukumoto, R Kyono, Y Shibukawa, Y Tanaka… - Journal of Biological …, 2024 - ASBMB
It is known that the recommended dietary allowance of selenium (Se) is dangerously close
to its tolerable upper intake level. Se is detoxified and excreted in urine as …

Solvent effect on the 77 Se NMR chemical shifts of diphenyl diselenides

RH Bartz, P dos Santos Hellwig, G Perin… - New Journal of …, 2024 - pubs.rsc.org
In this work, we have prepared some common diphenyl diselenide compounds and
evaluated the solvent effect on the 77Se NMR chemical shift. Thus, 77Se NMR spectra of …

Preserving the Integrity of Empirical Force Fields

AA Orr, S Sharif, J Wang… - Journal of chemical …, 2022 - ACS Publications
Generalized force fields (FFs) act as extensions to biomolecular FFs to provide a wide
coverage of organic molecules. However, their precise application to an arbitrary molecule …

Synergistic effect of lecithin and alginate, CMC, or PVP in stabilizing curcumin and its potential mechanism

WQ Cai, X Liu, W Chen, Z Huang, C Li, X Huang… - Food Chemistry, 2023 - Elsevier
This work aims to advance the understanding of the synergistic mechanism of lecithin and
polymers (alginate, CMC, and PVP) in stabilizing curcumin, with a major focus on …