SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

Two years into the COVID-19 pandemic: lessons learned

SJR da Silva, JCF do Nascimento… - ACS infectious …, 2022 - ACS Publications
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible
and virulent human-infecting coronavirus that emerged in late December 2019 in Wuhan …

SARS-CoV-2 simulations go exascale to capture spike opening and reveal cryptic pockets across the proteome

MI Zimmerman, G Bowman - Biophysical Journal, 2021 - cell.com
The SARS-CoV-2/COVID-19 pandemic continues to threaten global health and
socioeconomic stability. Experiments have revealed snapshots of many viral components …

SARS-CoV-2 and the host cell: a tale of interactions

M Pizzato, C Baraldi, G Boscato Sopetto… - Frontiers in …, 2022 - frontiersin.org
The ability of a virus to spread between individuals, its replication capacity and the clinical
course of the infection are macroscopic consequences of a multifaceted molecular …

The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

W Gu, H Gan, Y Ma, L Xu, ZJ Cheng, B Li, X Zhang… - Virology journal, 2022 - Springer
Abstract The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread …

Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases

S Kakavandi, I Zare, M VaezJalali, M Dadashi… - Cell Communication and …, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is caused by a new member of the
Coronaviridae family known as severe acute respiratory syndrome coronavirus 2 (SARS …

Predicting the locations of cryptic pockets from single protein structures using the PocketMiner graph neural network

A Meller, MD Ward, JH Borowsky, JM Lotthammer… - Biophysical journal, 2023 - cell.com
Cryptic pockets expand the scope of drug discovery by enabling targeting of proteins
currently considered undruggable because they lack pockets in their ground state structures …

SARS-CoV-2 non-structural proteins and their roles in host immune evasion

ZY Low, NZ Zabidi, AJW Yip, A Puniyamurti, VTK Chow… - Viruses, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …

[HTML][HTML] Circulating microRNAs as emerging regulators of COVID-19

Y Liang, D Fang, X Gao, X Deng, N Chen, J Wu… - Theranostics, 2023 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19), an infectious disease caused by the novel
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that …

Coronaviral RNA-methyltransferases: function, structure and inhibition

R Nencka, J Silhan, M Klima, T Otava… - Nucleic acids …, 2022 - academic.oup.com
Abstract Coronaviral methyltransferases (MTases), nsp10/16 and nsp14, catalyze the last
two steps of viral RNA-cap creation that takes place in cytoplasm. This cap is essential for …