Antibody-mediated encephalitis

J Dalmau, F Graus - New England Journal of Medicine, 2018 - Mass Medical Soc
Antibody-Mediated Encephalitis The category of autoimmune encephalitides constitutes
disorders with relatively distinct characteristics such as psychosis, seizures, abnormal …

Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin

TA Pollak, BR Lennox, S Müller, ME Benros… - The Lancet …, 2020 - thelancet.com
There is increasing recognition in the neurological and psychiatric literature of patients with
so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) …

Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis

D Dubey, SJ Pittock, CR Kelly, A McKeon… - Annals of …, 2018 - Wiley Online Library
Objective To evaluate the incidence and prevalence of autoimmune encephalitis and
compare it to that of infectious encephalitis. Methods We performed a population‐based …

Autoimmune encephalitis: clinical spectrum and management

CE Uy, S Binks, SR Irani - Practical neurology, 2021 - pn.bmj.com
Autoimmune encephalitis defines brain inflammation caused by a misdirected immune
response against self-antigens expressed in the central nervous system. It comprises a …

Acute symptomatic seizures secondary to autoimmune encephalitis and autoimmune‐associated epilepsy: conceptual definitions

C Steriade, J Britton, RC Dale, A Gadoth, SR Irani… - …, 2020 - Wiley Online Library
Seizures are a well‐recognized and often prominent manifestation of autoimmune
encephalitic syndromes. Progress in detection of pathogenic neural autoantibodies has led …

Seronegative autoimmune encephalitis: clinical characteristics and factors associated with outcomes

WJ Lee, HS Lee, DY Kim, HS Lee, J Moon, KI Park… - Brain, 2022 - academic.oup.com
Seronegative autoimmune encephalitis is autoimmune encephalitis without any identifiable
pathogenic antibody. Although it is a major subtype of autoimmune encephalitis, many …

LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory

M Petit-Pedrol, J Sell, J Planagumà, F Mannara… - Brain, 2018 - academic.oup.com
Abstract Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a
trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase …

LGI1 antibody encephalitis: acute treatment comparisons and outcome

A Rodriguez, CJ Klein, E Sechi, E Alden… - Journal of Neurology …, 2022 - jnnp.bmj.com
Objective To compare acute treatment responses and long-term outcome in leucine-rich
glioma-inactivated 1 (LGI1) antibody encephalitis. Methods Retrospective case series of 118 …

Randomized placebo‐controlled trial of intravenous immunoglobulin in autoimmune LGI1/CASPR2 epilepsy

D Dubey, J Britton, A McKeon, A Gadoth… - Annals of …, 2020 - Wiley Online Library
Objective Drug‐resistant seizures are common in patients with leucine‐rich, glioma‐
inactivated 1 (LGI1)‐IgG associated and contactin‐associated protein‐like 2 (CASPR2)‐IgG …

LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes

SNM Binks, CJ Klein, P Waters, SJ Pittock… - Journal of Neurology …, 2018 - jnnp.bmj.com
Recent biochemical observations have helped redefine antigenic components within the
voltage-gated potassium channel (VGKC) complex. The related autoantibodies may be now …