Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis
is tightly coordinated during bone development. However, the molecular regulators of …

The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …

Recent evidence suggests that physical exercise (EX) promotes skeletal development.
However, the impact of EX on the progression of bone loss and deterioration of mechanical …

The gut microbiota (GM) is referred to as the second gene pool of the human body and a
commensal, symbiotic, and pathogenic microorganism living in our intestines. The …

Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of bone fragility
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …

Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …

Abstract Hydrogen sulfide (H 2 S), known as the third gasotransmitter, exerts various
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …

Rationale: Manipulation of the gut microbiome can prevent pathologic bone loss. However,
the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in …