Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …
Cystathionine-β-synthase: molecular regulation and pharmacological inhibition
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …
pathway, is an important mammalian enzyme in health and disease. Its biochemical …
[HTML][HTML] Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice
Rationale: Emerging evidence indicates that the growth of blood vessels and osteogenesis
is tightly coordinated during bone development. However, the molecular regulators of …
is tightly coordinated during bone development. However, the molecular regulators of …
Modulation of bone remodeling by the gut microbiota: a new therapy for osteoporosis
Z Lyu, Y Hu, Y Guo, D Liu - Bone research, 2023 - nature.com
The gut microbiota (GM) plays a crucial role in maintaining the overall health and well-being
of the host. Recent studies have demonstrated that the GM may significantly influence bone …
of the host. Recent studies have demonstrated that the GM may significantly influence bone …
Exercise-linked skeletal irisin ameliorates diabetes-associated osteoporosis by inhibiting the oxidative damage–dependent miR-150-FNDC5/pyroptosis axis
Recent evidence suggests that physical exercise (EX) promotes skeletal development.
However, the impact of EX on the progression of bone loss and deterioration of mechanical …
However, the impact of EX on the progression of bone loss and deterioration of mechanical …
The role of gut microbiota in bone homeostasis
J Behera, J Ison, SC Tyagi, N Tyagi - Bone, 2020 - Elsevier
The gut microbiota (GM) is referred to as the second gene pool of the human body and a
commensal, symbiotic, and pathogenic microorganism living in our intestines. The …
commensal, symbiotic, and pathogenic microorganism living in our intestines. The …
Pathophysiology and management of type 2 diabetes mellitus bone fragility
C Eller-Vainicher, E Cairoli, G Grassi… - Journal of Diabetes …, 2020 - Wiley Online Library
Individuals with type 2 diabetes mellitus (T2DM) have an increased risk of bone fragility
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …
fractures compared to nondiabetic subjects. This increased fracture risk may occur despite …
Gut microbiota and bone metabolism
L Lu, X Chen, Y Liu, X Yu - The FASEB Journal, 2021 - Wiley Online Library
Osteoporosis is the most common metabolic skeletal disease. It is characterized by the
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …
deterioration of the skeletal microarchitecture and bone loss, leading to ostealgia, and even …
On-demand therapeutic delivery of hydrogen sulfide aided by biomolecules
Y Ge, F Rong, W Li, Y Wang - Journal of Controlled Release, 2022 - Elsevier
Abstract Hydrogen sulfide (H 2 S), known as the third gasotransmitter, exerts various
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …
physiological functions including cardiac protection, angiogenesis, anti-inflammatory, and …
[HTML][HTML] Probiotics stimulate bone formation in obese mice via histone methylations
Rationale: Manipulation of the gut microbiome can prevent pathologic bone loss. However,
the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in …
the effects of probiotics on mitochondrial epigenetic remodeling and skeletal homeostasis in …