So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …

Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

The impact of chromosomal inversions on human brain morphology remains underexplored.
We studied 35 common inversions classified from genotypes of 33,018 adults with European …

Ageing‐associated tauopathies like frontotemporal dementia (FTD), variants thereof (like
progressive supranuclear palsy (PSP), pick diseases (PiD), corticobasal degeneration …

Intracellular accumulation of hyperphosphorylated misfolded tau proteins are found in many
neurodegenerative tauopathies, including Alzheimer's disease (AD). Tau pathology can …

Dementia currently affects about 55 million people worldwide, with Alzheimers disease (AD)
being the most prevalent form. The one crucial pathological hallmark of AD that correlates …

The microtubule-associated protein Tau is highly enriched in axons of brain neurons where
it regulates axonal outgrowth, plasticity, and transport. Efficient axonal Tau sorting is critical …

DNA methylation, the main epigenetic modification regulating gene expression, plays a role
in the pathophysiology of neurodegeneration. Previous evidence indicates that 5′-flanking …

DNA methyltransferases (DNMTs) are widely expressed in the brain, dictating the
transcriptional activity of genes through various epigenetic mechanisms. Functional …

Emerging evidence indicates that resolution of inflammation is a critical and dynamic
endogenous process for host tissues defending against external invasive pathogens or …