Limited understanding of human proteoforms with complex posttranslational modifications
and the underlying mechanisms poses a major obstacle to research on human health and …

Chemical synthesis of complex peptides and proteins continues to play increasingly
important roles in industry and academia, where strategies for covalent ligation of two or …

Site-specific protein modification techniques have led to breakthroughs across diverse
fields, such as cell imaging, proteomics, biomaterials, and pharmaceutical protein and …

Abstract The 2-((2-chloroethyl) amino) ethane-1-thiol (CAET)-based chemical trapping
strategy is a practical tool for mechanistic studies of E3-catalysed ubiquitination. However …

Ataxia Telangiectasia (AT) is a rare hereditary childhood neurodegenerative disease that
has no known cure. Similar to other neurodegenerative disorders, AT is characterized by the …

Background: The ubiquitin–proteasome system (UPS) is responsible for most protein
degradation and its malfunction is normally observed in Alzheimer's disease (AD). The …