Peptides are a growing therapeutic class due to their unique spatial characteristics that can
target traditionally “undruggable” protein–protein interactions and surfaces. Despite their …

Recently, owing to their special spatial structures, peptide-based macrocycles have shown
tremendous promise and aroused great interest in multidisciplinary research ranging from …

β-Strands are a fundamental component of protein structure, and these extended peptide
regions serve as binding epitopes for numerous protein–protein complexes. However …

Photochemical reactions have been the subject of renewed interest over the last two
decades, leading to the development of many new, diverse and powerful chemical …

Site-specific conjugation to cysteines of proteins often uses ester groups to link maleimide or
alkene groups to polymers. However, the ester group is susceptible to hydrolysis, potentially …

Disulfide bonds are an essential feature of many bioactive peptides, however, they are labile
to reducing conditions which can limit therapeutic application. Herein, we report an efficient …

Polyampholytes, widely investigated for their distinct properties, are typically prepared via
conventional polymerisation techniques. This results in an ensemble of polymer chains with …

The acid-catalyzed thiol–ene reaction (ACT) is a unique thiol–X conjugation strategy that
produces S, X-acetal conjugates. Unlike the well-known radical-mediated thiol–ene and …

Dehydroalanine (ΔAla) is a highly electrophilic residue that can react efficiently with sulfur
nucleophiles to furnish cysteinyl analogues. Herein, we report an efficient synthesis of N …

Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have
been synthesized via solid-phase peptide synthesis and SN 2'reaction on a Morita–Baylis …