Despite advances in uncovering the mechanisms that underlie neuroinflammation and
neurodegenerative disease, therapies that prevent neuronal loss remain elusive. Targeting …

Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …

Hexanucleotide expansions in C9orf72, which encodes a predicted guanine exchange
factor, are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and …

Misfolded, potentially toxic proteins in the lumen and membrane of the endoplasmic
reticulum (ER) are eliminated by proteasomes in the cytosol through ER-associated …

Astrocytes contribute to motor neuron death in amyotrophic lateral sclerosis (ALS), but
whether they adopt deleterious features consistent with inflammatory reactive states remains …

Several neurodegenerative disorders involve impaired neurotransmission, and
glutamatergic neurotransmission sets a prototypical example. Glutamate is a predominant …

Classically, the loss of vulnerable neuronal populations in neurodegenerative diseases was
considered to be the consequence of cell autonomous degeneration of neurons. However …

Astrocytes and microglia are brain‐resident glia that can establish harmful inflammatory
environments in disease contexts and thereby contribute to the progression of neuronal loss …

Astrocytes play crucial roles in regulating brain circuit formation and physiology. Recent
technological advances have revealed unprecedented levels of astrocyte diversity …

Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease with poor
prognosis. The intricacies surrounding its pathophysiology could partly account for the lack …