Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

A functional interplay of bottom‐up and top‐down processing allows an individual to
appropriately respond to the dynamic environment around them. These processing …

Depression symptoms are often found in patients suffering from chronic pain, a
phenomenon that is yet to be understood mechanistically. Here, we systematically …

The central mechanisms underlying pain chronicity remain elusive. Here, we identify a
reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the …

Aversion refers to feelings of strong dislike or avoidance toward particular stimuli or
situations. Aversion can be caused by pain stimuli and has a long-term negative impact on …

Dysfunction in the mesocortical pathway, connecting the ventral tegmental area (VTA) to the
prefrontal cortex, has been implicated in chronic pain. While extensive research has focused …

Mental disorders such as anxiety and depression induced by chronic pain are common in
clinical practice, and there are significant sex differences in their epidemiology. However …

Diabetic neuropathic pain (DNP) is a diabetes complication experienced by many patients.
Ventrolateral periaqueductal gray (vlPAG) neurons are essential mediators of the …

Neuropathic pain is an intractable chronic pain, caused by damage to the somatosensory
nervous system. To date, treatment for neuropathic pain has limited effects. For the …

Neuropathic pain is a debilitating condition that is often refractory to treatment. The network
of neural substrates for pain transmission and control within the brain is complex and …