The calcium-sensing receptor (CaSR) has played an important role as a target in the
treatment of a variety of disease states over the past 20 plus years. In this review, we give an …

Class CG protein-coupled receptors (GPCRs) recognise diverse extracellular stimuli and are
highly tractable drug targets for a host of different psychiatric, neurological and metabolic …

Drugs that allosterically target the human calcium-sensing receptor (CaSR) have substantial
therapeutic potential, but are currently limited. Given the absence of high-resolution …

Cinacalcet hydrochloride (cinacalcet), an oral calcimimetic agent has been widely used for
the management of secondary hyperparathyroidism (SHPT) in chronic kidney disease …

The current interest of the scientific community for research in the field of calcium sensing in
general and on the calcium-sensing Receptor (CaR) in particular is demonstrated by the still …

Pancreatic acinar cells require high rates of amino acid uptake for digestive enzyme
synthesis, but excessive concentrations can trigger acute pancreatitis (AP) by mechanisms …

The extracellular calcium receptor (CaR) is a Family CG protein-coupled receptor that
controls systemic Ca2+ homeostasis, largely by regulating the secretion of parathyroid …

Atherosclerosis, the underlying cause of the majority of cardiovascular diseases (CVDs), is a
lipid-driven, inflammatory disease of the large arteries. Gold standard therapy with statins …

Melanoma is a common and aggressive skin cancer caused by the oncogenic
transformation of melanocytes. NPS-2143 (hydrochloride) is a calcification drug that acts as …

A series of urea based calcimimetics was optimized for potency and oral bioavailability.
Crucial to this process was overcoming the poor pharmacokinetic properties of lead thiazole …