Plants are sessile in nature and they perceive and react to environmental stresses such as
abiotic and biotic factors. These induce a change in the cellular homeostasis of reactive …

Monoclonal antibodies are susceptible to chemical and enzymatic modifications during
manufacturing, storage, and shipping. Deamidation, isomerization, and oxidation can …

Carbonylation is a posttranslational modification (PTM or PTLM), where a carbonyl group is
added to lysine (K), proline (P), arginine (R), and threonine (T) residue of a protein molecule …

Neurodegenerative diseases (NDD) such as Alzheimer's (AD) and Parkinson's disease (PD)
are distinct clinical entities, however, the aggregation of key neuronal proteins, presumably …

Motivation Protein carbonylation is one of the most important oxidative stress-induced post-
translational modifications, which is generally characterized as stability, irreversibility and …

Patients with type 2 diabetes (T2D) are more susceptible to severe respiratory viral
infections, but the underlying mechanisms remain elusive. Here, we show that patients with …

Oxidative stress alters cell viability, from microorganism irradiation sensitivity to human
aging and neurodegeneration. Deleterious effects of protein carbonylation by reactive …

Posttranslational modifications (PTMs) play an important role in regulating protein folding,
activity and function and are involved in almost all cellular processes. Identification of PTMs …

Succinylation is a type of protein post-translational modification (PTM), which can play
important roles in a variety of cellular processes. Due to an increasing number of site …

Background The correct determination of protein–protein interaction interfaces is important
for understanding disease mechanisms and for rational drug design. To date, several …