Mammalian genomes express two principal gene categories through RNA polymerase II-
mediated transcription: protein-coding transcription units and non-coding RNA transcription …

Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Gene expression is controlled in a dynamic and regulated manner to allow for the consistent
and steady expression of some proteins as well as the rapidly changing production of other …

Transcribing RNA Polymerase II interacts with multiple factors that orchestrate maturation
and stabilisation of messenger RNA. For the majority of noncoding RNAs, the polymerase …

The transcriptional termination of unstable non-coding RNAs (ncRNAs) is poorly understood
compared to coding transcripts. We recently identified ZC3H4-WDR82 (" restrictor") as …

The 3′ ends of almost all eukaryotic mRNAs are generated in an essential two-step
processing reaction: endonucleolytic cleavage of an extended precursor followed by the …

Summary The mammalian pre-mRNA 3′-end-processing machinery consists of cleavage
and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and other …

Transcription termination by RNA polymerase II (RNA Pol II) is linked to RNA 3′ end
processing by the cleavage and polyadenylation factor (CPF or CPSF). CPF contains …

Transcription termination pathways mitigate the detrimental consequences of unscheduled
promiscuous initiation occurring at hundreds of thousands of genomic cis-regulatory …

Most eukaryotic messenger RNAs (mRNAs) are processed at their 3′ end by the cleavage
and polyadenylation specificity factor (CPF/CPSF). CPF mediates the endonucleolytic …