Challenges in the design of a T cell vaccine in the context of HIV-1 diversity
M Tongo, WA Burgers - Viruses, 2014 - mdpi.com
The extraordinary variability of HIV-1 poses a major obstacle to vaccine development. The
effectiveness of a vaccine is likely to vary dramatically in different populations infected with …
effectiveness of a vaccine is likely to vary dramatically in different populations infected with …
High degree of HIV-1 group M (HIV-1M) genetic diversity within circulating recombinant forms: insight into the early events of HIV-1M evolution
The existence of various highly divergent HIV-1 lineages and of recombination-derived
sequence tracts of indeterminate origin within established circulating recombinant forms …
sequence tracts of indeterminate origin within established circulating recombinant forms …
Anti-V3/glycan and anti-MPER neutralizing antibodies, but not anti-V2/glycan site antibodies, are strongly associated with greater anti-HIV-1 neutralization breadth …
The membrane-proximal external region (MPER), the V2/glycan site (initially defined by PG9
and PG16 antibodies), and the V3/glycans (initially defined by PGT121–128 antibodies) are …
and PG16 antibodies), and the V3/glycans (initially defined by PGT121–128 antibodies) are …
HIV-1 integrase diversity and resistance-associated mutations and polymorphisms among integrase strand transfer inhibitor-naive HIV-1 patients from Cameroon
SG Mikasi, JO Gichana, C Van der Walt… - AIDS research and …, 2020 - liebertpub.com
The World Health Organization (WHO) has put forth recommendations for the use of
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …
integrase (IN) strand transfer inhibitors (INSTIs) to be part of the first-line combination …
Predominance of CRF63_02A1 and multiple patterns of unique recombinant forms of CRF63_A1 among individuals with newly diagnosed HIV-1 infection in …
NM Gashnikova, DP Zyryanova, EM Astakhova… - Archives of …, 2017 - Springer
Kemerovo Oblast (KO) has had the highest rate of HIV spread in Russia since 2011. The aim
of this work was to study the genetic variation of HIV-1 in Kemerovo Oblast. Blood was …
of this work was to study the genetic variation of HIV-1 in Kemerovo Oblast. Blood was …
Subtype classification of Iranian HIV-1 sequences registered in the HIV databases, 2006-2013
Background The rate of human immunodeficiency virus type 1 (HIV-1) infection in Iran has
increased dramatically in the past few years. While the earliest cases were among …
increased dramatically in the past few years. While the earliest cases were among …
Unravelling the complicated evolutionary and dissemination history of HIV-1M subtype A lineages
Subtype A is one of the rare HIV-1 group M (HIV-1M) lineages that is both widely distributed
throughout the world and persists at high frequencies in the Congo Basin (CB), the site …
throughout the world and persists at high frequencies in the Congo Basin (CB), the site …
Phylogenetic evidence of extensive spatial mixing of diverse HIV-1 group M lineages within Cameroon but not between its neighbours
From the perspective of developing relevant interventions for treating HIV and controlling its
spread, it is particularly important to comprehensively understand the underlying diversity of …
spread, it is particularly important to comprehensively understand the underlying diversity of …
No detectable differences in Nef-mediated downregulation of HLA-I and CD4 molecules among HIV-1 group M lineages circulating in Cameroon, where the pandemic …
HIV-1 group M (HIV-1M) lineages downregulate HLA-I and CD4 expression via their Nef
proteins. We hypothesized that these Nef functions may be partially responsible for the …
proteins. We hypothesized that these Nef functions may be partially responsible for the …
Structural Features and Genetic Diversity in Gag Gene of Rare HIV-1 Subtypes from the Democratic Republic of Congo
Type-1 HIV (HIV-1) group M (HIV-1M) genetic diversity is highest in the Congo Basin where
the epidemic ignited a century ago. HIV-1M has diversified into multiple subtypes, sub …
the epidemic ignited a century ago. HIV-1M has diversified into multiple subtypes, sub …