The title to a seminar presentation by IC Gunsalus in 1973 was “Oxygen: An essential toxin”,
referring to the complex role that atmospheric dioxygen has in biology. The relatively simple …

Cytochromes P450 are ubiquitously distributed enzymes, which were discovered about 50
years ago and which possess high complexity and display a broad field of activity. They are …

The development of catalytic systems for the controlled oxidation of C–H bonds remains a
highly sought-after goal in chemistry owing to the great utility of such transformation toward …

Biocatalysis is an enabling technology adding to organic oxidation chemistry. Especially the
high selectivity of enzymatic oxidation coevally operating under mild conditions and not …

Isoprenoids are a large and highly diverse group of natural products with many functions in
plant primary and secondary metabolism. Isoprenoids are synthesized from common prenyl …

Although catalytic reductions, cross‐couplings, metathesis, and oxidation of C C double
bonds are well established, the corresponding catalytic hydroxylations of C H bonds in …

Conspectus The preparation of complex molecules (eg, biologically active secondary
metabolites) remains an important pursuit in chemical synthesis. By virtue of their …

Cytochrome P450 monooxygenases are versatile biocatalysts that introduce oxygen into a
vast range of molecules. These enzymes catalyze diverse reactions in a regio-and …

The selective oxyfunctionalization of isolated sp3 C–H bonds in complex molecules
represents a formidable challenge in organic chemistry. Here, we describe a rational …

The cytochromes P450 (P450s) are a broad class of heme b-containing mono-oxygenase
enzymes. The vast majority of P450s catalyse reductive scission of molecular oxygen using …